2025 AIChE Annual Meeting

Session: Poster Session: Pharmaceutical Discovery, Development, and Manufacturing

Please join us for a poster session to highlight work focused on Pharmaceutical Discovery, Development, and Manufacturing.

Chair

Michael Lovette, Eli Lilly

Co-Chair

Vaclav Svoboda, University of Strathclyde

Presentations

(191k) Recombinant Adeno-Associated Virus As Gene Delivery Vehicles Targeting the Heart
Hwayeon Lim, Seulhee Kim, X. Margaret Liu, Lufang Zhou
(191y) CD276-Targeted Antibody-Drug Conjugate in Combination with Cancer Mitochondria Targeting Gene Therapy to Treat Triple-Negative Breast Cancer
Tanvi Varadkar, Zhuoxin Zhou, Alyssa Fairgrieve, Lufang Zhou, X. Margaret Liu
(191z) Machine Learning Models for Predicting Monoclonal Antibody Biophysical Properties from Molecular Dynamics Simulations and Deep Learning-Based Surface Descriptors.
I-En Wu, Lateefat Kalejaye, Pin-Kuang Lai
(191aa) Assessing High-Concentration Monoclonal Antibody Viscosity Using Deep Learning and High-Throughput Small-Angle X-Ray Scattering
Lateefat Kalejaye, Pin-Kuang Lai, I-En Wu, Jia-Min Chu, Neil Mody, Jenna Caldwell, Madison Kreitz, Austin Gallegos, Alison Hinton, Monica Castellanos, Mitali Shah, Maryam Pouryahya, Mehdi Boroumand, Valentin Stanev, Bismark Amofah, Amber Lee, Mark Hutchinson, Chacko Chakiath, Andrew Dippel, Gilad Kaplan, Melissa Damschroder
(191d) Continuous Pharmaceutical Processing with Thin-Film Evaporation: Enhancing Scale-up Efficiency
Csky Silva
(191ad) Aspartase (AspA) Mediated Persistence State in Escherichia coli
Rauf Shiraliyev, Sayed Golam Mohiuddin, Mehmet A. Orman
(191ab) Balancing Binding Affinity and Helical Stability: A Helix–Coil Transition–Informed Approach to Peptide Design
Corey Febo, Carol Hall
(191ac) Advanced Characterization and Machine Learning for Preclinical Differentiation and Optimization of Lyophilized Vaccine Formulations
Leia Epstein, Tyler Yager, Eric Kemp, Rahul Upadhya
(191as) Practical Pathways of Building Machine Learning Models Using CAE Simulation Data: Case Studies for Pharma Unit Operations and Deployment Strategies for Democratization
Indrajit Jagtap
(191ai) Evaluation of Antihypertensive and Antidiabetic Potential of Bioactive Peptides from White, Red, and Black Quinoa
María Isabel Valdez Cárdenas, Cintya Soria-Hernández, Karla Lopez-Carrasco, Gilmar Peña-Rojas, Vidalina Andía-Ayme, Cristina Chuck-Hernández
(191aj) Advancements in Tangential Flow Filtration: Ceramic Membrane Performance Analysis
Ankur Kapil, Michael Hamlin
(191ap) Scalable Microfluidic Production of Well-Controlled Micro-Drug Delivery Systems
Anna Tsitouridou, Maryam Parhizkar, Chaun-Yu Wu, Tao Chen, Dimitrios Tsaoulidis
(191b) Characterizing Continuous Extraction and Separation Platforms for API Manufacturing: Enabling Cycle Time Reduction and Enhanced Product Stability
Heather Boucher, Joseph Imbrogno, Courtney Talicska, Steven Guinness, Michele Buetti-Weekly
(191an) Pressure-Driven Sterile Filtration of a Model Vaccine Adjuvant
Titania Bethiana, Kurt Ristroph
(191l) Coarse-Grained Insights into How Poloxamer 188 Stabilizes AAV8 Capsids Against Aggregation
Leila Sharifi, Jahanbakhsh Ghasemi, Mario Congiu, Shivangi S. Naik, Willow DiLuzio, Arani Chanda, Bodhisattwa Chaudhuri
(191ak) Hybrid Modeling Based Process Development in Cell Therapy, Gene Therapy and mRNA Processes
Kevin Healy
(191m) Fluroquinolone Mediated Mutagenesis and Its Effect on Drug Tolerance/Resistance
Sreyashi Ghosh, Jenet Narzary, Mehmet A. Orman
(191n) Co-Crystallization of Acetaminophen and Zinc Via a Solution-Mediated Crystallization Technique
Dale Vert Zimon Manansala
(191o) A Domain-Focused Generative AI Framework for Automated Biopharmaceutical Process Development
Abrahim Mahmud, Mohammed Aatif Shahab, Elia Arnese Feffin, Richard D. Braatz
(191f) Raman Spectral Signature Analysis & Model Development for Real-Time Monitoring and Control of Lipid Nanoparticle (LNP) Production in Continuous Biomanufacturing Processes
Marianna Sofman, Hossein Hamedi, Rikki Kaufman, Nisha A. Patel, Aula Al Muslim, Kaschif Ahmed, Edita Botonjic-Sehic, Aaron Cowley
(448g) Breaking the Boundaries of Bayesian Optimization Utilizing Continuous Chemistry Digital Twins
Bao Chau, Yuma Miyai, Tom Roper
(191av) GMP Flow Chemistry Platforms: A CDMO Perspective on Enabling the Next Generation of Clinical-Stage API Manufacturing
Rudi Oliveira, Nuno Lousa
(191aw) Oriented multivalent display drives consistent serum antibody responses to the Ebola virus glycoprotein
Chu Zheng, Adonis A Rubio, Sheena Vasquez, Dominic Pham, Zhangyuan Pan, Christopher O. Barnes, Peter Kim
(191ah) Dual-Payload Antibody-Drug Conjugate Targets and Treats EpCAM Positive Triple-Negative Breast Cancers
Tanvi Varadkar, Jiashuai Zhang, Chandini Tsaliki, Aaron Krabacher, X. Margaret Liu
(191al) Determining the Desolvation Window of a Prolific Solvate Former Using Experimental and Computational Approaches
Eric Dybeck, Giselle P. Reyes, Brian Samas
(191au) Enhancing Digital Twin Development through Human-Machine Collaboration: Insights from a Pan-Coating Scale-up Case Study
Michael Choi, Axel Meisen
(191c) Efficient Development of a Continuous Low-Temperature Process from a Modified Katritzky Benzotriazole Hemiaminal
Thomas Bass
(191q) Syringability and Physical Stability of Pre-Filled Intra-Mammary Injectors
Joshua Katzenstein, Madeleine Gonley, Gregory M. Troup
(191ae) Advancing Flow Photochemistry: Kg-Scale Implementation of a Laser-Driven Continuous Photoreactor
(191aq) Powder Rheological Properties of Pharmaceutical Excipients: Lactose Monohydrate and Carboxymethyl Cellulose
Behbood Abedi
(588ai) Optimization Approaches for Improved Peptide Synthesis Including Downstream Separation
Megan E. Walsh, Paridhi Agrawal, Jennifer M. Groh, Mark Berglund, Jingyao Wang, Bhoja Kandela, Casey Smith, Shekhar Viswanath, Carl Laird, Chrysanthos Gounaris
(191am) Electron Diffraction (MicroED): A Dedicated Device and Its Applications in the Pharmaceutical Industry
Danny Stam, Gustavo Santiso-Quinones, Christian Jandl, Johannes Merkelbach, Laura Samperisi
(191r) An Innovative Workflow to Generate Drying Curves in Real Time
Jason Yu, Eduardo Madrigal, Zhenqi Shi, Derek Dalton, Lady Mae Alabanza
(191at) Enhancing Design Space Identification through Prediction Reliability Assessment: The Prep Framework
Seyed Saeid Tayebi, Todd Hoare, Prashant Mhaskar
(191p) Mathematical Modeling of Particle Size Distribution in Lipid Nanoparticle Fabrication: A Population Balance Equation Approach
Sunkyu Shin, Cedric Devos, Aniket Udepurkar, Pavan Inguva, Allan Myerson, Richard D. Braatz
(191s) Multiscale Analysis of Cooperative Modifier Effects on Inhibition and Dissolution of Calcium Oxalate Monohydrate Crystals
Vraj P. Chauhan, Jeffrey Rimer
(191t) No More Lost in Translation: A Pan-European Strategy to Deliver Nanomedicine to Cancer Patients
Sabrina Pricl
(191u) Experimental Approach to Determine K-Value Impact on Critical Quality Attributes (CQAs) in Diffusive Batch Blending
Joel Francis, Kanishka Ghosh, Joshua Hanson
(191ao) Heterogeneous Transfer Learning for Batch and Continuous Manufacturing Transitions in Pharmaceutical Tablet Production
Junya Ihira, Keita Yaginuma, Kanta Sato, Shota Kato, Manabu Kano
(191e) A Quality By Design Approach for Fault Detection and Diagnosis in Twin-Screw Granulation
Kavitha Sivanathan, Prashant Mhaskar, Michael Thompson
(191af) Anti-CD166 Antibody-Dual Drug Conjugate for to Treat Non-Small Cell Lung Cancer
Jiashuai Zhang, Zhuoxin Zhou, Emily Claypool, X. Margaret Liu
(191ag) Mitochondria-Targeted Gene Therapy Combined with Antibody-Drug Conjugate for Glioblastoma Treatment
Zhantao Du, Tanvi Varadkar, Aaron Krabacher, X. Margaret Liu
(191v) Engineered Lipolysis-Stimulated Lipoprotein Receptor Monoclonal Antibody to Target and Treat Triple-Negative Breast Cancer
Zhuoxin Zhou, Jiashuai Zhang, Zhantao Du, X. Margaret Liu
(191w) A Humanized Antibody-Drug Conjugate to Treat Non-Small Cell Lung Cancers
Jiashuai Zhang, Zhantao Du, Tanvi Varadkar, X. Margaret Liu
(191x) Humanized Anti-SSTR2-Mmaf Antibody-Drug Conjugate for the Treatment of Meningioma
Zhantao Du, Zhuoxin Zhou, Jiashuai Zhang, X. Margaret Liu