2025 AIChE Annual Meeting

Session: 15D Poster session: Engineering Fundamentals in Life Science

This poster session highlights recent advances utilizing engineering fundamentals to understand and control living systems. The work presented encompasses themes including biomolecular engineering; cell and tissue engineering; cell-, organ- and lab-on-a-chip technologies; drug delivery; micro- and nano-scale biotechnology; and systems biology.

Chair

Panagiotis Mistriotis, Auburn University

Co-Chairs

Jessica Larsen, Clemson University
Molly Kozminsky, University of California, Berkeley
Rajib Saha, University of Nebraska-Lincoln
Laurel Hind, University of Colorado Boulder
Vivek Bajpai, Stanford University
Lawrence Stern, University of South Florida
Mattheos Koffas, Rensselaer Polytechnic Institute

Presentations

(183l) Inhibition of Glutaminolysis Restores Mitochondrial Metabolism and Extends Lifespan in Prematurely Aged Mice
Hamsa Vardini Senthil Kumar, Debanik Choudhury, Pedro Lei, Dilip Kumar Gollamoni, Sai Harsha, Karthik Ramachandran, Stelios Andreadis
(183ao) Hydrophobic Counterion and Co-Encapsulated Hydrophobic Small Molecule Chemistries Influence Assembly Kinetics of Liquid Crystalline Mesophases in Nanoparticle Cores
Sophia Dasaro, Lucas Johnson, Malinda Salim, Vincent He, Ellie Ponsonby-Thomas, Bryce Barber, Nigel Kirby, Benjamin Boyd, Kurt Ristroph
(183r) Exploring the Molecular Mechanism Underlying Neutrophil Upstream Migration
Subham Guin, Aman Mittal, Alexander Buffone
(183ag) Shining Light on Calcium-Mediated Morphogenesis: Forward Engineering Organ Development with Optogenetics
Mayesha Mim, Zian Wang, Jeremiah Zartman
(183ah) In silico Characterization of the Molecular Basis for the Cross-Reactivity of VEGFA- and PLGF2-Targeting Antibodies for Cancer Treatment
Emma Aldrich, Samuel Blackman, Jennifer Maynard, Kayla Sprenger
(183ad) Reverse Engineering Morphogenesis through Bayesian Optimization of Physics-Based Models
Nilay Kumar, Mayesha Mim, Alexander Dowling, Jeremiah Zartman
(183h) Atomistic Simulations Reveal Phosphorylation-Dependent Conformational Shifts in the Disordered N-Terminus of c-Myc1-88
Kosar Rahimi Nasrabadi, Eduardo Ayala, Gül Zerze
(183c) Modeling Changes in Binding Affinity (??G) of Protein-Peptide Complexes Using the Pepbi Database
Jazmine Torres, Chris Kieslich, Robert J. Pantazes
(183t) Engineered Proteoliposomes for the Elucidation of Protein Activity
Marjon Zamani, Ariel Furst
(183k) Derivation of Skeletal Myoblasts from Human Hutchinson-Gilford Progeria Syndrome iPSCs As a Model of Muscle Aging
Shahryar Shahini, Stelios Andreadis
(183d) Role of Tail-Specific Protease in Ampicillin Tolerance
Jenet Narzary, Aslan Massahi, Sayed Golam Mohiuddin, Mehmet A. Orman
(183ap) Harnessing miRNA Target Sites for Cell-Specific mRNA Therapeutics
George Katsarakes, Shaoyi Jiang
(183o) Evaluation of the Transduction of Murine Endocrine Pancreatic Cells with Different Serotypes of Adeno-Associated Virus
Vishal Ahuja, Sanjeev Jeyabalan, Emmanuel Tzanakakis
(183e) Classification of Human Transcription Factors Based on Activation Domains Using Unsupervised Learning on Sequence Properties
Eduardo Ayala, Ayush Gupta, Nehil Shreyash, Arvind Ramanathan, Gül Zerze
(183ae) Decoding Phase Behavior of Human Transcription Factors through Systematic Classification and Simulations
Eduardo Ayala, Gül Zerze
(183n) Bioprocess Sensor for iPSC Culture Online Monitoring and Automation
Zahra Foroozan Jahromi, Seongkyu Yoon, Zhao Youbo
(183f) Asymmetric Transition Pathways Govern the Conformational Landscape of the Sars-Cov-2 Frameshifting Stimulatory Element
Karim Malekzadeh, Gül Zerze
(183g) Transfer Learning from Large Language Models for Biology Predicts an Antibiotic Resistance Phenotype from Genotype
Dongheon Lee, Emrah ?im?ek, Lingchong You
(183aq) High-Throughput Screening of Bacterial Ghost–GPCR Interactions for Targeted Drug Delivery
Chris Vidmar, Joshua Wilkinson, David Roman, Jennifer Fiegel
(183u) Developing a Mucus-Mimetic System to Study Mechanisms of Respiratory Droplet Formation
Ziting Tan, Fred Foueppe, Sima Asadi
(183p) Exploring the Impact of Cell-Cell Junction Strength on Spheroid Stiffness Using Extensional Flow Microfluidic Device
Sara Ghanbarpour Mamaghani, Jonathan Celli, Joanna Dahl
(183q) Dancing through Mucus: Unveiling Bacterial Motion in the Gut
Abdullah Bin Murad, Taylor Carlson, Sara Hashmi, Rebecca L. Carrier
(183ax) Modeling of population balance approach for Process Analytical Technology as a tool for crystallization to predict particle size distribution of API
Sandip Sawarkar, Vishwanath Dalvi
(183x) Imaging of Intra-Matrix IgG Diffusion As an Indicator of Age-Related Vitreous Changes
Riya Debbarma, Antonio dos Santos, Diana Ramirez Gutierrez, Kendra A. Erk, Fernanda Cunha, Michael Ladisch
(183af) Genome Metabolic Network Reconstruction of Erythroxylum Novogranatense to Increase Non-Cocaine Value Added Molecules
Johan Nicolas, Diana Marcela Bernal Franco, Maria Francisca Villegas Torres, Andres Fernando Gonzalez Barrios
(183m) A Mesofluidic Intestinal Model to Investigate Immune-Epithelium-Lumen Interactions
Daniel Bell, Chia-Ming Wang, Yuan Li, Rebecca L. Carrier
(183at) A Physiologic Culture Platform for Examining Cell-Environment Interactions Relevant to Human Health and Disease
Jason Cantor
(183av) 3D Bioprinted Viscoelastic Muscle Constructs for Enhanced Regeneration in Volumetric Muscle Loss
Peng Zhao, Yunzhi Yang
(183ak) A Model-Based Design of Experiments Approach for Accurate Injection Time Prediction in Autoinjectors
Andrea Friso, Federico Galvanin
(183aa) Structural and AI-Based Immunoinformatics for Highly Pathogenic Livestock Virus Intervention
Supantha Dey, Rahil Salehi, Hannah Gates, Balaji Narasimhan, Mike Roof, Md Sakib Ferdous, Jennifer Bruner, Maria Brown, Ratul Chowdhury
(181h) Structural Underpinnings of Lanmodulin Dimer for Competitive Lanthanide Binding
Rahil Salehi, Hannah Gates, Karuna Anna Sajeevan, Dan Park, Joseph Cotruvo, Jr., Ratul Chowdhury
(183aj) Unraveling the Molecular Interaction between Human Serum Albumin and a Self-Assembling Gallium C18 Nanocarrier: A Breakthrough in PET Imaging.
Anna Laura La Monaca, Sabrina Pricl
(183ab) Engineering Human Brain Assembloids to Investigate Forebrain and Choroid Plexus Interactions Under BMP4 and Wnt Signaling Modulation
Falak Syed, Justice Ene, Yan Li
(183ac) Dual Role of Skn-1: The Regulation of Neuronal Activity and Oxidative Stress Resistance in C. Elegans
Hrishikesh Mane, Adriana San Miguel
(183a) Molecular Simulations to Reveal Selective Antimicrobial Activity of Peptoids on Bacterial Membranes
Adwoa Onomah, Mingfei Zhao
(183as) Enhanced Chemotherapeutic Delivery and Efficacy in Melanoma Treatment Via Magnetite Nanobioconjugates
Erika Diaz, Valentina Quezada, Javier Cifuentes, Nydia Arias-Morales, Luis Reyes, Carolina Muñoz-Camargo, Juan Cruz
(183z) Systems Level Study of Antibiotic Persistence Mechanisms
Alden Filko, Yichao Han, Fuzhong Zhang
(183y) Fluid-Mediated Microplastic Uptake and Its Impact on Tissue Cell Functions
Qin NI, Jinfu Fu, Dean Sharif, Sean X. Sun
(183v) In Vitro Model of Staphylococcus Epidermidis Biofilm Development at the Vascular Interface
Lily Gaudreau, Elizabeth Stewart
(183ai) Development of a Compartmental Metabolism Rate Model for Glucose Transformation to Non-Digestible Oligosaccharides in the Proximal Small Intestine.
Adedayo Adeboye, Edesiri Ukusajuya, Kazeem Olanrewaju
(183aw) Engineering Structurally Diverse Pbae Nanoparticles to Restore Tumor Immunogenicity Via Antigen Processing Machinery Delivery
Grace Shoemaker, Jack Kollings, Ryan Idnani, Lance Xu, Romina Blanco-Sarmiento, Kevin Zhang, Stephany Tzeng, Jordan Green, Joel Sunshine
(183b) Engineered HIV-Capturing Liposomes to Facilitate Immune Uptake
Keunsil Kang, Peter Deak, Irwin Chaiken, Charles Ang, Monisha Gupta, Derek Yang
(183al) Thermodynamic Insights into Mucin–Drug Interactions: Implications for Supersaturation Stability in Amorphous Solid Dispersion Polymers.
Victus Kordorwu, Steven Castleberry, Steve Lustig, Rebecca L. Carrier
(183am) Engineering Brain-Tropic Adeno-Associated Virus for Precision Gene Therapy in Glioblastoma
Eunji Lee, Eunhyun Ji, Kye Il Joo
(183an) Development of 3D-Printed Hypromellose Structure for Poorly Soluble Drug
Jin Zhao, Tracy Zhang, Kevin O'Donnell, Robert Bubeck, Ian Gillespie, Thomas Watson, Stephanie Robart, Kennedy Holt, Evelyn Johnson
(183ar) Design of the Next Generation Liposomal Encapsulation of Polysaccharide (LEPS) Vaccine for Pneumococcal Disease.
Yihui Chen, Blaine Pfeifer, Justin Bassett