The proximal small intestine, along with other supporting organs, plays a vital role in the digestion, transport, and transformation of dietary macromolecules into bioactive nutrients such as glucose, that enter the bloodstream. The gastrointestinal tract functions as a tubular organ comprising several compartments—namely the stomach, proximal small intestine, pancreas, and large intestine—each designated for specific stages of digestion. This study positions the proximal small intestine as a central compartment, with the supporting organs represented as peripheral compartments, facilitating the transfer of nutrients at their interfaces, albeit at varying rates. The metabolic rate model developed in this study simulates the physiological processes of the digestive system, allowing for in vitro examination of these dynamics. Compartmentalization is shown to enhance metabolic efficiency. Accordingly, the primary objective of this research is to create a metabolism rate model for glucose transformation to non-digestible Oligosaccharides in the proximal small intestine. This presentation focuses on reviewing information from several journal articles, books, and online sources, detailing the process of designing the metabolic model. It will discuss various modeling frameworks and mathematical representations, contributing to a deeper understanding of glucose remediation and optimization in the proximal intestine, particularly through the transformation of glucose substrates into non-digestible oligosaccharides.
