2024 AIChE Annual Meeting

Session: Poster session: Engineering Fundamentals in Life Science

This poster session highlights recent advances utilizing engineering fundamentals to understand and control living systems. The work presented encompasses themes including biomolecular engineering; cell and tissue engineering; cell-, organ- and lab-on-a-chip technologies; drug delivery; micro- and nano-scale biotechnology; and systems biology.

Chair

Co-Chairs

Jessica Larsen, Clemson University
Panagiotis Mistriotis, Auburn University

Presentations

(175ae) “Transport Cocktails” of Alpha-Particle Radionuclide-Antibody Conjugates for Solid Tumors
Aira Sarkar, Rajiv Ranjit Nair, Rohit Chaudhari, Pooja Hariharan, Kathleen Gabrielson, Stavroula Sofou
(175y) The Excess Surface Area of the Nuclear Lamina Determines Whether Cells Can Migrate through Narrow Constrictions.
Richard B. Dickinson, Brendan McKee, Ting Ching Wang, Kajol Harsh, Simran Kaur, Mohammed Mohajeri, Tanmay Lele
(175bi) Navigating Biological Systems with PBPK, Text Mining, and AI: In silico NAMS for the Development of Reliable and Robust Qaops
Achilleas Karakoltzidis, Elisavet Renieri, Nafsika Papaioannou, Ilias Frydas, Thanasis Papageorgiou, Dayna Schultz, Catherine Gabriel, Nancy Georgiou, Spyros Karakitsios, Dimosthenis Sarigiannis
(175bd) An Interdisciplinary Framework Based on High-Dimensional Biology for a Comprehensive Understanding of the Effects of Environmental Stressors on Non-Communicable Diseases
Nafsika Papaioannou, Catherine Gabriel, Spyros Karakitsios, Dimosthenis Sarigiannis
(175bg) Metabolic Systems Biology of Poplar, a Biofuel Crop
Funke Okunrinboye, Ganesh Sriram
(175z) Mathematical Modeling of Gut-Mediated Inflammation Induced By Estrogen Deficiency
Ariel Lighty, Brenda J. Smith, Ashlee N. Ford Versypt
(175d) Connecting the Unfolded Protein Response and DNA Damage Response: The Role of IRE1 in DNA Damage Repair Pathways Under Elevated Levels of Palmitate.
Kevin Chen, Sean Foster, Caleb Sandum, Yogit Goyal, Samantha Zaloudek, S. Patrick Walton, Christina Chan
(175as) Incorporating Biological Factors Using Different Carrier Materials to Accelerate Implant Healing Capacity
Dina Gadalla, Jamie Ganem, Maeve Kennedy, David Lott
(175at) Coaxial 3D Bioprinting of Hydrogels with Small Diameters to Mimic Microvasculature
Berk Uysal, Sundararajan Madihally
(175bf) Assessing the Metabolic Responses of 3D Heparg Cells to Dibutyl Phthalate and DEHP Exposure: Insights from Untargeted Metabolomics
Thanasis Papageorgiou, Nafsika Papaioannou, Dayna Schultz, Catherine Gabriel, Charbel Touma, Spyros Karakitsios, Sophie Langouet, Dimosthenis Sarigiannis
(175be) Integrated Omic Analysis Elucidates Phenotypic Plurality and Metabolic Bottlenecks in Industrial Antibody-Producing Chinese Hamster Ovary (CHO) Cell Lines
Saratram Gopalakrishnan, Miguel Angel Valderrama-Gomez, William Johnson, Jasmine Tat, Elcin Icten Gencer, Cleo Kontoravdi, Nathan Lewis
(175ad) High-Throughput Screening of Bacterial Ghost Drug Delivery Vehicles Against G-Protein Coupled Receptors (GPCRs)
Christopher Vidmar, Joshua Wilkinson, David Roman, Jennifer Fiegel
(175f) Overcoming the Challenges of Fluoro-Pharmaceutical Encapsulation Via Flash Nanoprecipitation through Solubility Parameter Matching
Kiana Bahrami, Parker Lewis, Gülse Kayra O?uz, Nathalie M. Pinkerton
(175a) Cluster Formation of Macrophages Depends on Their Activation
Lawrence J. Dooling, Nicholas M. Ontko, Tristan Marchena, Dennis E. Discher
(175af) Messenger RNA Loaded Lipid Nanoparticle Delivery and Gene Expression in Trophoblast Cells Is Impacted By Ionizable Lipid Content
Alexandra Harrison, Christina Bailey-Hytholt
(175ag) Non-Targeted and Targeted Lipid Drug-Loaded Nanoparticle Combination Delivery Outperforms Either Component in Metastatic Ovarian Cancer Treatment
Basar Bilgicer, Jenna Sjoerdsma, Emily Bromley, Jaeho Shin, Caitlin Horgan, Gyoyeon Hwang, Tanyel Kiziltepe, David Omstead, Sharon Stack
(175g) Retinal Progenitor Cell Differentiation By Electrical Stimulation on Microcircuit Interfaces
Austin Sympson, Madison Chng, Michael R. Kumar, Donald S. Sakaguchi, Surya Mallapragada
(175aa) Silver Nanoparticle Sensor Array for the Detection of Sars-Cov?2 for Engineering Fundamentals in Life Science
Benjamin Lam
(175bj) Causal Discovery Algorithms Identify DNA Methylation Sites That Differentiate COPD Progression
Robert Gregg
(175ah) Intracerebral Nanoparticle Transport Facilitated By Alzheimer Pathology and Age
Gregory C. Tracy, Kai-Yu Huang, Yu-Tong Hong, Shengzhe Ding, Hayden A. Noblet, Ki H. Lim, Eung Chang Kim, Hee Jung Chung, Hyunjoon Kong
(175ai) Conformational Flexibility: Elasticizing Phospholipid Membranes
Thomas Kinard, Steven P. Wrenn
(175ab) Assessing Plasticity in Prostate Cancer Using Electrokinetic Techniques
Lexi Crowell, Luis Henriquez, Mary Tran, Juan Sebastian Yakisich, Brian Aufderheide, Tayloria N.G. Adams
(175aj) Apoptosis of Myrosinase Gene Expressed Lung Cancer Cells Treated with Glucosinolate-Containing Extracellular Vesicles Isolated from Arabidopsis thaliana
Sharjeel Jokhio, Ching-An Peng
(175h) Developing an Elastic Dome for the Study of Cell Mechanobiology
Gideon Nyarko, Carla M. R. Lacerda
(175ac) High-Accuracy Nanopore Sequencing of 6-Letter DNA for Synthetic Biology Applications
Nicholas Kaplan, Jorge A. Marchand
(175bc) Quantifying the Consequences of New Plasmid Acquisition
Allison Lopatkin, Habibul Islam
(175ak) Optimizing Solid Tumor Treatment with Antibody-Drug Conjugates Using Agent-Based Modeling: Considering the Role of a Carrier Dose and Payload Class
Melissa Calopiz, Jennifer Linderman, Greg Thurber
(175r) Promising Routes for Mitigating RBC Storage Lesion
Linh Tran, Cristina González-Fernández, Mitchell Weigand, Jacob Strayer, Xian Wu, Hyeon Choe, Eugenio Bringas, Inmaculada Ortiz, Jeffrey Chalmers, Jenifer Gomez Pastora
(175bk) Dynamic Model of Intrathymic T-Cell Vs Myeloid Commitment
Sana Khanum, Shakti Gupta, Mano Maurya, Shankar Subramaniam, Doraiswami Ramkrishna
(175av) An Engineered Culture Model to Mimic the Physical Boundary Conditions of the Lung Epithelium
Evelyn Navarro Salazar, Sherry X. Zhang, Phoebe A. Marshall, Celeste M. Nelson
(175s) CRISPR/Cas9-Mediated Genome Editing to Generate Cell Wall-Deficient Tobacco By-2 Cell Lines for Improved Recombinant Protein Production
Jianfeng Xu
(175am) Engineering a Next-Generation Vaccine: Targeting Pneumococcal Disease in an Aging Population
Justin Bassett, Manmeet Bhalla, Miles Stefko, Elena Lopez, Elsa Bou Ghanem, Blaine Pfeifer
(175t) An in-Situ Hydrogen Sulfide Synthesis and Delivery Technique for Treatment and Healing of Chronic Wounds
Bill J. Brooks, Debra M. Friedrichsen, Rob Beckius, Grayson Silaski, Deepali Kulkarni, Carolyn Pace, Ross M. Clark, Reza Shekarriz
(175an) Enhanced Delivery of Disease-Targeted Nanobody-siRNA Conjugates
Courtney Culkins, Blaise Kimmel
(175bb) Elucidating and Engineering the Mechanism of Microbial Thermogenesis
Stephen Chiu, Puneet Dhatt, Tae Seok Moon
(175ao) Endoplasmic Reticulum (ER) Stress-Induced Autophagy Alters the Efficacy of Cationic-Lipid Delivered Sirnas
Ryan Splichal, Christina Chan, S. Patrick Walton
(175j) Anti-Senescence Effects of Human Blood Vessel Organoid-Derived Extracellular Vesicles
Justice Ene, Colin Esmonde, Yeoheung Yun, Takahisa Kanekiyo, Changchun Zeng, Yan Li
(175u) Engineering an ?-P-Selectin Antibody for Quantifying Drug Delivery in Glioblastoma
Omar Abed, Timon Lwo, James Moon, Colin Greineder
(175n) Functional Characterization of Geraniol Synthase Involved in Monotropein Biosynthesis in Blueberry Using Computational and Molecular Based Approaches
Ishveen Kaur
(175ap) Evaluation on Plant-Based Softgels (SeaGel® Technology) Versus Gelatin Softgels for Pharmaceutical Applications
Jin Zhao, Becca Putans, Ian Gillespie, Michael Evangelista, Thomas Watson, Stephanie Robart, Brooklynn Jonassen, Hannah Bishop, Benjamin Roscoe, Michael Baumann
(175w) Applying Engineered Microenvironments to Assess Structural and Mechanical Remodeling of the Cytoskeleton in Hypertrophic Cardiomyopathy
Georgina Stephanie
(175k) Dynamics of Circulating Tumor Cells inside Microfluidic Separators
Emmanuel I. Ezeobidi, Agnieszka Truszkowska
(175x) Fructose Effects on PC3 Cells Using GLUT5 Transport Receptor
Martin Guerrero
(175aw) Hydrogel Facilitated Co-Culture Tumor Microenvironment
Trishita Chowdhury, Muhammad Raisul Abedin, Vanshika Singh, Jordan Yaron, Kaushal Rege
(175l) Investigating the Cross-Talk between Insulin and Glucagon Secretion By Pancreatic Alpha- and Beta-Cells
Vishal Ahuja, Kevin Fuentes, Emmanuel Tzanakakis
(175ax) Transcriptional Regulation of Engineered Living Materials
Gina Partipilo, Austin J. Graham, Benjamin Keitz
(175ay) Cell Compatible Fluid Gels for Applications in Tissue Engineering
Cinzia Amieni, Armend Håti, David Bassett
(175m) Engineered Dual Universal CAR-Natural Killer Cells from Human Pluripotent Stem Cells for Targeted Cancer Immunotherapy
Xiaoping Bao
(175az) Elucidating the Geometric and Charge Transfer Effects on the Spatial Uniformity of the Nanopore Electroporation Cell Transfection Method
Emily McCorkle, Matthew Manion, Sasha Cai Lesher-Pérez, Albert Liu
(175o) Discovering Novel Ankyrin Protein Modulators through an Optimized Yeast Surface Display System
Ethan Slaton, Samantha Martinusen, Cassidy Simas, Marian Pulgar, Sage Nelson, Carl Denard