(175ai) Conformational Flexibility: Elasticizing Phospholipid Membranes

Some biomolecules, including but not limited to Triglycerides (TGs) and Diglycerides (DGs), exhibit the unique and novel property of Conformational Flexibility upon incorporation into biological membranes. Like phospholipids, these molecules can occupy interfacial (water/oil) positions in membrane leaflets. In contrast, however, they can also occupy midmembrane positions or isotropic oil phases of their own. Most interestingly, they are able to flexibly transition between interfacial and midmembrane positions in response to changes in lateral tension/area.

In this work, we introduce and characterize the property of Conformational Flexibility, defining a class of biomolecules. Additionally, we demonstrate some unique applications of these molecules. Methods employed include monolayer characterization via Langmuir-Blodgett Trough, ultrasonic characterization, and fluorescent leakage assays. The behavior of these molecules can be of use in design of ultrasound-triggered drug delivery systems, as well as of other therapeutic and diagnostic tools. Further, the behavior of TGs and DGs in synthetic systems may provide insight into their roles in biological processes.