2025 AIChE Annual Meeting

Session: Mixing Issues in Scale-Up and Scale-Down of Pharmaceutical & Biopharmaceutical Processes

Mixing issues and scale-up/scale-down strategies for the production of pharmaceutical and biopharmaceuticals.

Chair

Matthew Flamm, Merck & Co., Inc.

Co-Chair

Presentations

08:00 AM

(496a) Bioprocess Design Improvement for Aggregation-Prone Peptides
Rachel Murphy, Niall Brady

08:30 AM

(496b) Blend Time Prediction: Effect of Dosing Location and Impeller Rpm Using CFD Approach
James Morgan Harris, Laura Caboni, Hossam Metwally, Mustafa Kaddoura

09:00 AM

(496c) Beyond Kla: How Reaction and Transport Timescales Compete in High-Cell-Density Bioprocesses
John Thomas, Brian DeVincentis, Eric Janz

09:30 AM

(496d) Industrial Scale-up of Combined Cooling-Antisolvent Crystallization: A Compartmental-Population Balance Modeling Approach
Yung-Shun Kang, Antonello Raponi, Almos Orosz, Guanghui Zhu, Neda Nazemifard, Charles Papageorgiou, Zoltan Nagy

10:00 AM

(496e) Understanding Risk of Dissolved Gas Gradients in Sparged Systems
Matthew Flamm, Zbynek Kalal