2025 AIChE Annual Meeting

(654b) Microrobots for Cell Fate Control

Authors

Sambeeta Das - Presenter, University of Pennsylvania
Ceren Kirmizitas, University of Delaware
Sudipta Mallick, University of Delaware
We introduce a magnetically controlled microrobot (MR) platform for guiding mammalian cells to desired locations that, combined with synthetic biology deliver biological signals at precise locations, enabling spatiotemporal control of cell-fate decision-making. We first demonstrate a 3-pair orthogonal Helmholtz coil system used to guide MR-loaded cells to deliver chemical signals at precise locations in a Chinese hamster ovary (CHO) cell culture, activating target receiver cells to express a fluorescent protein.