(2x) Mesoscale Self-Organization of Biomolecular Condensates

Cells function via a complex reaction network that relies on the spatial organization of its components. Phase separation is integral for regulating this reaction network. Despite their ubiquity and importance, the general organizational principles of reaction-coupled phase transitions remain a profound and compelling problem. This is especially true for non-equilibrium environments, where the interplay of chemical reactions and phase separation exhibit rich behaviors that cannot be accurately described by existing (i.e. equilibrium) methods. A model experimental system consisting of DNA nanostars, where relevant phase-separating properties such as size, valence and interaction strength/specificity are encoded in DNA sequence, provides remarkable design precision, flexibility and biochemical compatibility to investigate these complex systems. I propose to use this model system to interrogate open questions regarding the organizational mechanisms of phase-separated bio-inspired materials, including exotic photonic materials, condensation-triggered reaction networks, and synthetic cellular tissues.

Teaching Interests

As an educator, I am especially interested in teaching courses in statistical mechanics (thermodynamics), computational physics (simulation methods) and dynamical systems. I would also like to develop a course to explore the interplay of dynamics and structures in complex materials and how these exotic structures can be exploited for technological applications. As a mentor, I take pride in the accessibility of my research, such that undergraduates, graduate students and postdocs can thrive equally in an environment where new research projects are tailored to students' strengths and interests.