(623f) Direct Co-Crystal Assembly from Synthesis to Co-Crystallization

Pharmaceutical co-crystals were assembled directly via chemical synthesis by cooling under three new strategies. The screening method for direct co-crystal assembly by a chemical reaction was developed based on liquid-assisted grinding. The ternary phase diagram including a chemical reaction and co-crystallization was established for a 2 : 1 co-crystal of benzoic acid–sodium benzoate.