2016 AIChE Annual Meeting

Session: Poster Session: Pharmaceutical

Poster Session: Pharmaceutical

Chair

Jacob Albrecht, Bristol-Myers Squibb Co.

Co-Chair

Zoltan K. Nagy, Purdue University

Presentations

03:15 PM

Material Science
(233t) Continuous Manufacturing of Co-Crystals in Twin Screw Extruder: A Case Study
Shaza Darwish, Rahamatullah Shaikh, Manuel Kuhs, Denise Croker, Gavin Walker
Green Processing
(233n) Fault-Tolerant Control Design and Risk MAP Based Resiliency Analysis of Continuous Solid Dose Manufacturing
Mariana Moreno, Sudarshan Ganesh, Qinglin Su, Arun Giridhar, Gintaras Reklaitis, Zoltan K. Nagy
(233z) Wet Granulation-Induced Polymorphic Transitions in Piracetam: Raman Spectroscopy As a Potential in-Situ Process Analytical Tool
Gayathri Kollamaram, Catherine Kelly, Denise Croker, Gavin Walker
Drug Delivery
(233h) A Comprehensive Statistics-Based Approach to Proactive Process Analysis Including Multivariate Analysis Methods
Sara Koynov, Paige Adack, Jennifer Sun, Conor McCurdy, Orlaith Crowther, Michelle Cleary, Anthony Ruane, Dearbhla Carr, Eoin O'Brien
(233az) Dissolvable Microcarriers for Efficient Cell Production and Recovery
Yue Zhou, Jennifer L. Weber, Kathleen Krebs, Martial Hervy, Marylene Pecheul, Corinne Walerack, David Henry, Marie-Maud Bear, Stephen Caracci
Pharmacokinetics
Drug Discovery
(233y) PAT Application in Expedited Development of Multi-Step Chemical Syntheses of Active Compounds
Dominique Hebrault, Nizar Haddad
(233af) The Effect of Particle Engineering on the Processing and the in Vitro Performance of Inhalation Blends in Dry Powder Inhalers
Eva Faulhammer, Sarah Zellnitz, Johannes G. Khinast, Amrit Paudel, Thomas Wutscher
(233ay) The Utilization of Amino Acid Consumption Rate Assessment As a Tool for CHO Clonal Stability Evaluation.  
Eric Brodean, Andrew Seletsky, Melissa Good, Wai Lam Ling
(233ax) Process Innovation and Optimization of a Commercial Cell Culture Process
Sivaprakash Agastin, Sivashankar Sivakollundu, Jeffrey Savard, Simpson Gregoire
(233aw) Feasibility Analysis of Flowsheet Models in Continuous Pharmaceutical Manufacturing Processes Considering the Effects of Noise
Zilong Wang, M. Sebastian Escotet-Espinoza, Ravendra Singh, Fernando J. Muzzio, Marianthi G. Ierapetritou
(233c) Integrated Flowsheet Modeling and Experimental Validation in Dry Granulation for Pharmaceutical Excipients: Effects of Changes in Roller Compactor Parameters on Granules
Seo-Young Park, Shaun Galbraith, Bumjoon Cha, Huolong Liu, Zhuangrong Huang, Hae Woo Lee, Seongkyu Yoon
(233x) Process Understanding for Antisolvent Cocrystallization Based on Near-Infrared and Raman Spectroscopic Measurements
Guang J. Choi, Min-Yong Cho, Min-Jeong Lee
(233i) Design of Nonlinear Observer for State Estimation of a Bioreactor
Xinghua Pan, Tejasvi Jaladi, Jonathan Raftery, Melanie DeSessa, M. Nazmul Karim
(233ag) Characterization of Compaction Behaviour of Powders in Solid-Dosage Manufacturing Using Finite Element Analysis
Ashish Kumar, Jens Dhondt, Johny Bertels, Didier Klingeleers, Krist V. Gernaey, Ingmar Nopens, Thomas De Beer
(233e) Computational Fluid Dynamics (CFD) Guided Scale up of Cell Culture Bioreactors from Bench to Pilot to Commercial Scale
William Tran, Garima Chaudhary, Jan-Erik Schaefer, Erik Hasenfus, Thomas Wucherpfennig, Daniel Bock, Henry Lin
(233aq) Gender-Dependent PBPK Modeling
Ioannis P. Androulakis, Megerle Scherholz, Patrick J. Sinko, Marianthi Ierapetritou, Clara Hartmanshenn
(233l) Model-Based Process Analysis in Continuous Manufacturing of Pharmaceuticals: Calibration of a Fluid Bed Dryer Model
Michael Ghijs, Ingmar Nopens, Thomas De Beer, Valérie Vanhoorne, Krist V. Gernaey, Daan Van Hauwermeiren, Fien De Leersnyder, Jurgen Vercruysse, Séverine T.F.C. Mortier, Philippe Cappuyns
(233au) Powder Tester Comparison to Predict Discharge Rate from Hoppers and Filling Tablet Press Dies
Joerg Theuerkauf, Yi Fan, Andrew Horton, Madhusudhan Kodam, Karl Jacob
(583a) Spray Drying of Ternary Solid Dispersions of Ibuprofen and Indomethacin with Superior Physical Stability
Ahmad B. Albadarin, Pishnamazi Mahboubah, Barbara Schaller, Ahmad Ziaee, Gavin Walker
(233m) Exploring the Design Space of a Novel Tablet Coating Process in a Continuous Manufacturing Line
Andrew Birkmire, Charles Cunningham, Sean Gilliam
(233o) Characterization of Mixing and Heat Transfer in Continuous Lab Scale Reactors
Jerry S. Salan, David am Ende
(233p) Development of a Model Predictive Tool for Continuous Manufacturing of Solid Oral Dosage Forms Via Roller Compaction
Barbara Schaller, Pishnamazi Mahboubah, Patrick Cronin, Ahmad Ziaee, Ahmad Albadarin, Denise Croker, Maurice Collins, Gavin Walker
(233a) Chemical Engineering Principles in Oral Solid Dosage Process Development-Where Are We?
Weixian Shi
(233q) Application of Model-Predictive Control to a Feeding Blending Unit
Jakob Rehrl, Julia Kruisz, Stephan Sacher, Martin Horn, Johannes G. Khinast, Isabella Aigner
(233j) Effect of Formulation Hydrophobicity on the Wet Granulation Growth Behavior
Madeline Candelaria
Pharmaceutical Manufacturing
(233aj) Green Synthesis of Carboxylic Acids from Ethyl Acetates Derivatives Using K2CO3 Under Microwave Irradiation
Eugenio Hernández-Fernández, Jorge Hernández-Fernández, Viviana Rodríguez-Torres, Norma Tiempos-Flores, Susana López-Cortina
(233ai) Systematic Technoeconomic Comparison of Separation Solvents for Green Continuous Pharmaceutical Manufacturing of Diphenhydramine
Samir Diab, Dimitrios Gerogiorgis
(233ah) Green Synthesis of Acetamides from Ethyl Acetates Under Base Free Conditions and Microwave Irradiation
Norma Tiempos-Flores, Eugenio Hernández, Susana López Cortina, Yhoana Medina
(233as) Screening a Library of Commercially Available Compounds for Drugs with Novel Anti-Biofilm Activity
Anand Ramasubramanian, Jose Lopez-Ribot, Kai Leung, Anand Srinivasan, Johnathan Abercrombie, Nelson Torres
(233u) Continuous Wet Granulation in a Twin Screw Extruder: Effect of Process Variables on Residence Time Distribution and Granule Characteristics
Ahmad Albadarin, Manuel Kuhs, Gayathri Kollamaram, Shaza Darwish, Rahamatullah Shaikh, Saeed Shirazian, Denise Croker, Gavin Walker, Jacek Zeglinski
(233av) A Small Volume Continuous Facility for GMP API Manufacture
Rick Spencer
(233ad) Controlling amorphization versus crystallization of carbamazepine nanoparticles using a supercritical-assisted spray drying process
Luis Padrela, Kevin M. Ryan, Barry Long
(233an) Evaluation of the Therapeutic Potential of FOXC1 Knockdown for Treatment of Basal-Like Breast Cancers
Landon A. Mott
(233aa) Real-Time Monitoring and Ejection of out-of-Spec Tablets Via NIR Chemical Imaging
Patrick R. Wahl, Gregor Hauseder, Stephan Sacher, Matthias Kerschhaggl, Johannes G. Khinast
(233k) Residence Time Distribution Analysis for a Hot Melt Granulation Process Using Positron Emission Particle Tracking and NIR and Raman Spectroscopic Probes
Patrick Wray, Keely Bergqvist, John Jones, Martin Vernon, Gary McGeorge, Andrew Dennis
(233ar) Virtual High-Throughput Screening Pipeline: Limitation Characterization and Application to Different Targets
Jonathan J. Chen, Donald Visco
(233ap) Prediction of Formulation Effects of Continuously Formulated Solid Oral Dosage Forms on Bioavailability Using PBPK Modeling
Clara Hartmanshenn, Ioannis P. Androulakis, Marianthi G. Ierapetritou, Patrick J. Sinko
(233ao) Predicting the In Vivo Performance of Amorphous Solid Dispersions Based on Molecular Descriptors and Statistical Analysis
Íris Duarte, João Henriques, João F. Pinto, Márcio Temtem
(233am) Modeling and Simulation Efforts in Scale up of Sustained Release Microspheres
Rishi Mehan, SVB Janardhan Garikipati, Birendra K. David, Yash Partani, RaviChandra Palaparthi
(233d) Multivariate Statistical Process Control for the Continuous Manufacturing of Solid Oral Dosage Forms
Salvador Garcia-Munoz, Zhenqi Shi, Joshua Hanson
(233b) Combined Task Bayesian Optimization for Efficient Scale-up and Technology Transfer
Ryosuke Yoshizaki, Manabu Kano
(233r) Behaviour of Magnesium Stearate in Continuous Feeding
Raghu V. G. Peddapatla, Caroline A. Blackshields, Michael F. Cronin, Abina Crean
(233g) Modelling Approaches to Spray Drying Process Development, Scale-up and Troubleshooting
Pedro Valente, Íris Duarte, Filipe Neves, Márcio Temtem
(233v) Development and Optimization of a Mixed Suspension Mixed Product Removal (MSMPR) Crystallization Process Incorporating Wet-Milling 
Yihui Yang, Charles D. Papageorgiou