2016 AIChE Annual Meeting

Session: Poster Session: Pharmaceutical

Poster Session: Pharmaceutical

Chair

Jacob Albrecht, Bristol-Myers Squibb Co.

Co-Chair

Zoltan K. Nagy, Purdue University

Presentations

03:15 PM

(233ah) Green Synthesis of Acetamides from Ethyl Acetates Under Base Free Conditions and Microwave Irradiation
Norma Tiempos-Flores, Eugenio Hernández, Susana López Cortina, Yhoana Medina
(233al) The Effects of Formulation Factors on the Aerosolization Performance of Metered Dose Inhalers
Denise S. Conti, Jay Holt, Poonam Sheth, Dennis Sandell, Anthony Hickey, Bhawana Saluja
(233ae) Exploiting Solvent and Impurity Effects to Modify Crystal Shape and Bulk Powder Properties of API and Intermediate Molecules
Anil Rane
(233t) Continuous Manufacturing of Co-Crystals in Twin Screw Extruder: A Case Study
Shaza Darwish, Rahamatullah Shaikh, Manuel Kuhs, Denise Croker, Gavin Walker
(233n) Fault-Tolerant Control Design and Risk MAP Based Resiliency Analysis of Continuous Solid Dose Manufacturing
Mariana Moreno, Sudarshan Ganesh, Qinglin Su, Arun Giridhar, Gintaras Reklaitis, Zoltan K. Nagy
(233h) A Comprehensive Statistics-Based Approach to Proactive Process Analysis Including Multivariate Analysis Methods
Sara Koynov, Paige Adack, Jennifer Sun, Conor McCurdy, Orlaith Crowther, Michelle Cleary, Anthony Ruane, Dearbhla Carr, Eoin O'Brien
(233y) PAT Application in Expedited Development of Multi-Step Chemical Syntheses of Active Compounds
Dominique Hebrault, Nizar Haddad
(233ay) The Utilization of Amino Acid Consumption Rate Assessment As a Tool for CHO Clonal Stability Evaluation.  
Eric Brodean, Andrew Seletsky, Melissa Good, Wai Lam Ling
(233ax) Process Innovation and Optimization of a Commercial Cell Culture Process
Sivaprakash Agastin, Sivashankar Sivakollundu, Jeffrey Savard, Simpson Gregoire
(233i) Design of Nonlinear Observer for State Estimation of a Bioreactor
Xinghua Pan, Tejasvi Jaladi, Jonathan Raftery, Melanie DeSessa, M. Nazmul Karim
(233e) Computational Fluid Dynamics (CFD) Guided Scale up of Cell Culture Bioreactors from Bench to Pilot to Commercial Scale
William Tran, Garima Chaudhary, Jan-Erik Schaefer, Erik Hasenfus, Thomas Wucherpfennig, Daniel Bock, Henry Lin
(233au) Powder Tester Comparison to Predict Discharge Rate from Hoppers and Filling Tablet Press Dies
Joerg Theuerkauf, Yi Fan, Andrew Horton, Madhusudhan Kodam, Karl Jacob
(233o) Characterization of Mixing and Heat Transfer in Continuous Lab Scale Reactors
Jerry S. Salan, David am Ende
(233a) Chemical Engineering Principles in Oral Solid Dosage Process Development-Where Are We?
Weixian Shi
(233j) Effect of Formulation Hydrophobicity on the Wet Granulation Growth Behavior
Madeline Candelaria
(233aj) Green Synthesis of Carboxylic Acids from Ethyl Acetates Derivatives Using K2CO3 Under Microwave Irradiation
Eugenio Hernández-Fernández, Jorge Hernández-Fernández, Viviana Rodríguez-Torres, Norma Tiempos-Flores, Susana López-Cortina
(233ac) Comparing and Contrasting the Solid-State Esterification of APIs with Excipient: Computational and Experimental Assessment
Corinna Gressl, Michael Brunsteiner, Adrian L. Davis, Margaret Landis, Klimentina Pencheva, Garry Scrivens, Geoffrey Wood, Johannes G. Khinast, Amrit Paudel, Gregory Sluggett
(233as) Screening a Library of Commercially Available Compounds for Drugs with Novel Anti-Biofilm Activity
Anand Ramasubramanian, Jose Lopez-Ribot, Kai Leung, Anand Srinivasan, Johnathan Abercrombie, Nelson Torres
(233av) A Small Volume Continuous Facility for GMP API Manufacture
Rick Spencer
(233ad) Controlling amorphization versus crystallization of carbamazepine nanoparticles using a supercritical-assisted spray drying process
Luis Padrela, Kevin M. Ryan, Barry Long
(233an) Evaluation of the Therapeutic Potential of FOXC1 Knockdown for Treatment of Basal-Like Breast Cancers
Landon A. Mott
(233k) Residence Time Distribution Analysis for a Hot Melt Granulation Process Using Positron Emission Particle Tracking and NIR and Raman Spectroscopic Probes
Patrick Wray, Keely Bergqvist, John Jones, Martin Vernon, Gary McGeorge, Andrew Dennis
Fundamental Modeling and Multivariate Analysis
Continuous Processing
Process Analytic Technology
Material Science
Green Processing
Drug Delivery
Pharmacokinetics
Drug Discovery
Pharmaceutical Manufacturing
(233l) Model-Based Process Analysis in Continuous Manufacturing of Pharmaceuticals: Calibration of a Fluid Bed Dryer Model
Michael Ghijs, Ingmar Nopens, Thomas De Beer, Valérie Vanhoorne, Krist V. Gernaey, Daan Van Hauwermeiren, Fien De Leersnyder, Jurgen Vercruysse, Séverine T.F.C. Mortier, Philippe Cappuyns
(233b) Combined Task Bayesian Optimization for Efficient Scale-up and Technology Transfer
Ryosuke Yoshizaki, Manabu Kano
(233v) Development and Optimization of a Mixed Suspension Mixed Product Removal (MSMPR) Crystallization Process Incorporating Wet-Milling 
Yihui Yang, Charles D. Papageorgiou
(233f) Developing Process Models of Hydrogen Peroxide Decontamination in Pharmaceutical Manufacturing
Hirokazu Sugiyama, Keisho Yabuta, Haruka Futamura, Masahiko Hirao, Koji Kawasaki
(233ak) A Supersaturating Nanoscale Delivery System of Herbal Nutraceuticals Prepared Via Complexation with Polysaccharides
Kunn Hadinoto, Jia Wei Chew
(233w) Comparison of Raman and UV Spectroscopy for the in-Line Quantification of Active Ingredient in Pharmaceutical Semi-Solid and Liquid Formulations
Nils Bostijn
(233at) Application of Fragment Antibody for Detecting Prion-like Diseases
Bongmun Kang
(233s) Process Development for Continuous Extrusion and Pelletization of a Heat and Shear-Sensitive Formulation
Theresa R. Hörmann, Gerold Koscher, Stephan Laske, Johannes G. Khinast
(233z) Wet Granulation-Induced Polymorphic Transitions in Piracetam: Raman Spectroscopy As a Potential in-Situ Process Analytical Tool
Gayathri Kollamaram, Catherine Kelly, Denise Croker, Gavin Walker
(233az) Dissolvable Microcarriers for Efficient Cell Production and Recovery
Yue Zhou, Jennifer L. Weber, Kathleen Krebs, Martial Hervy, Marylene Pecheul, Corinne Walerack, David Henry, Marie-Maud Bear, Stephen Caracci
(233af) The Effect of Particle Engineering on the Processing and the in Vitro Performance of Inhalation Blends in Dry Powder Inhalers
Eva Faulhammer, Sarah Zellnitz, Johannes G. Khinast, Amrit Paudel, Thomas Wutscher
(233aw) Feasibility Analysis of Flowsheet Models in Continuous Pharmaceutical Manufacturing Processes Considering the Effects of Noise
Zilong Wang, M. Sebastian Escotet-Espinoza, Ravendra Singh, Fernando J. Muzzio, Marianthi G. Ierapetritou
(233c) Integrated Flowsheet Modeling and Experimental Validation in Dry Granulation for Pharmaceutical Excipients: Effects of Changes in Roller Compactor Parameters on Granules
Seo-Young Park, Shaun Galbraith, Bumjoon Cha, Huolong Liu, Zhuangrong Huang, Hae Woo Lee, Seongkyu Yoon
(233x) Process Understanding for Antisolvent Cocrystallization Based on Near-Infrared and Raman Spectroscopic Measurements
Guang J. Choi, Min-Yong Cho, Min-Jeong Lee
(233ag) Characterization of Compaction Behaviour of Powders in Solid-Dosage Manufacturing Using Finite Element Analysis
Ashish Kumar, Jens Dhondt, Johny Bertels, Didier Klingeleers, Krist V. Gernaey, Ingmar Nopens, Thomas De Beer
(233aq) Gender-Dependent PBPK Modeling
Ioannis P. Androulakis, Megerle Scherholz, Patrick J. Sinko, Marianthi Ierapetritou, Clara Hartmanshenn
(233am) Modeling and Simulation Efforts in Scale up of Sustained Release Microspheres
Rishi Mehan, SVB Janardhan Garikipati, Birendra K. David, Yash Partani, RaviChandra Palaparthi
(583a) Spray Drying of Ternary Solid Dispersions of Ibuprofen and Indomethacin with Superior Physical Stability
Ahmad B. Albadarin, Pishnamazi Mahboubah, Barbara Schaller, Ahmad Ziaee, Gavin Walker
(233m) Exploring the Design Space of a Novel Tablet Coating Process in a Continuous Manufacturing Line
Andrew Birkmire, Charles Cunningham, Sean Gilliam