2013 AIChE Annual Meeting

Session: Model Based Integrated Design of Pharmaceutical Drug Substance and Drug Product and Processes I

This session seeks contributions where the design of the pharmaceutical product or process has been aided with a mathematical model. The session is open to contributions from the drug substance and drug product side of the business. Authors are encouraged to highlight the downstream considerations in the design.

Chair

Jeremy Merritt, Eli Lilly and Company

Co-Chair

Salvador Garcia-Munoz, Eli Lilly and Company

Presentations

08:30 AM

(260a) Applications of Modeling and Simulating Moisture Profiles During Fluid Bed Granulation Process Development
John Cunningham, Steve Mehrman, Eric Sanchez, Mauricio Futran, Terry Murphy, James Weber, Adam Fermier, Ray Boucher, Andrew Skalkin

08:55 AM

(260b) Understanding Micro Environmental Thermodynamics of Tablet Coating Process Using Data Logger – Case Studies
Ganeshkumar A. Subramanian, Preetanshu Pandey, Jiangning Ji, Shruti Gour, Brian Zacour

09:20 AM

(260c) An Integrated Model for the Thermodynamics of the Film Coating Operation the Mixing Phenomena in the Drum and the Distribution of Properties in the Coated Tablet
Salvador Garcia-Munoz, Alejandro Cano, Jianfeng Li, Daniel O. Blackwood, Alfred Berchielli

09:45 AM

(260d) Experimental and Theoretical Study of Tablet Flow in a Lab Scale Pan Coater
Peter Böhling, Gregor Toschkoff, David Johnson, Jennifer Sun, Alan R. Silverman, Georg Scharrer, Johannes G. Khinast, Pavol Rajniak

10:10 AM

(260e) Use of Mechanistic Modeling to Understand Tablet Die Filling
RJ Byron Smith, Atul Dubey, Fernando J. Muzzio, Damodaran Vedapuri

10:35 AM

(260f) Application of Fracture Mechanics Model for the Characterization of Bilayer Tablets
Niranjan Kottala, Admassu Abebe, Omar L. Sprockel, Ilgaz Akseli, Faranak Nikfar, Alberto Cuitino