2013 AIChE Annual Meeting
(260a) Applications of Modeling and Simulating Moisture Profiles During Fluid Bed Granulation Process Development
Authors
Mehrman, S. - Presenter, PDMS
Cunningham, J., PDMS
Sanchez, E., Janssen Pharmaseuticals
Futran, M., Bristol-Meyers Squibb
Murphy, T., PDMS
Weber, J., PDMS
Fermier, A., Johnson & Johnson
Developing a robust fluid bed granulation process is often challenging due to a variety of equipment configurations and interrelated controls. To overcome these challenges we have been developing first principal modeling and simulation tools focused on moisture control profiling. Examples using these tools to model historical batch performance and simulation to design scale up and process DOE’s will be described.