2008 Spring Meeting & 4th Global Congress on Process Safety
(83y) Sequential Integration of Br-Li Exchange Reactions Using Microflow Systems
Authors
Aiichiro Nagaki - Presenter, Department of Synthetic Chemistry & Biological Chemistry, Graduate School of Engineering, Kyoto University
Yutaka Tomida - Presenter, Department of Synthetic Chemistry & Biological Chemistry, Graduate School of Engineering, Kyoto University
Jun-ichi Yoshdia - Presenter, Department of Synthetic Chemistry & Biological Chemistry, Graduate School of Engineering, Kyoto University
The Br-Li exchange of p-, m-, and o-dibromobenzenes followed by reactions electrophiles using microflow systems can be conducted at much higher temperatures than those required for conventional macro batch systems. The sequential integration of the processes provides a straightforward method for the synthesis of a variety of disubstituted benzenes.