2008 Spring Meeting & 4th Global Congress on Process Safety
(83y) Sequential Integration of Br-Li Exchange Reactions Using Microflow Systems
Authors
Nagaki, III, A. - Presenter, Department of Synthetic Chemistry & Biological Chemistry, Graduate School of Engineering, Kyoto University
Tomida, Y. - Presenter, Department of Synthetic Chemistry & Biological Chemistry, Graduate School of Engineering, Kyoto University
Yoshdia, J. - Presenter, Department of Synthetic Chemistry & Biological Chemistry, Graduate School of Engineering, Kyoto University
The Br-Li exchange of p-, m-, and o-dibromobenzenes followed by reactions electrophiles using microflow systems can be conducted at much higher temperatures than those required for conventional macro batch systems. The sequential integration of the processes provides a straightforward method for the synthesis of a variety of disubstituted benzenes.