2006 Spring Meeting & 2nd Global Congress on Process Safety
(15d) Mechanochemical Preparation of Nano-Sized Pharmaceutical Drugs for Application in Cancer Therapy
Authors
Woo Sik Choi - Presenter, Pusan National University
Peter Balaz - Presenter, Institute of Geotechnics, Slovak Academy of Sciences
Gyu-Jeong Noh - Presenter, University of Ulsan
Byung-Moon Choi - Presenter, University of Ulsan
Peter Jr. Balaz - Presenter, Institute of Clinical and Experimental Medicine
Min Jae Seong - Presenter, Pusan National University
Bong June Cha - Presenter, Insilicotech Co., Ltd.
Erika Godocikova - Presenter, Pusan National University
The mechanochemical transformation of ?Ñalfa-realgar As4S4 to its high temperature polymorph ?"beta- form has been studied. The size dependance of this transformation was elucidated for particle size 25-62 nm. The mechanochemical transformation is hindered by agglomeration effects in this case. The identified phenomena - polymorphous transformation, new surface area formation and preparation of realgar particles in nanosize - are expected to have good impact on solubility as well as bioavailability of realgar as a potential new pharmaceutical drug for leukemia treatment.