2025 AIChE Annual Meeting

Session: Predictive Scale-Up/Scale-Down for Bioprocessing

Chair

Jackie Gonzalez, Takeda Pharmaceuticals

Co-Chairs

Kevin Stone, Merck & Co., Inc.
David Dhanraj, Washington University

Presentations

03:30 PM

(224a) Development and Scale up of a Telescoped Process Manufacture of a Macrocyclic Peptide Intermediate
Bharath Krishnamurthi, Jonathan McMullen, Chihui An, Jeffery Kuethe

03:48 PM

(224b) Predicting and Optimizing Monoclonal Antibody (mAb) Production Using Mechanistic and Machine-Learning Hybrid Models: Towards a Bioreactor Digital Twin
Mariana Carvalho, Ajit Vikram, Kevin Stone, Avik Sarkar

04:06 PM

(224c) A Computational Methodology for the Optimization of Mab Produced in Dissolved Oxygen Heterogeneous Bioreactors
Katherine Henderson, Marianthi Ierapetritou

04:24 PM

(224d) Data Efficiency and Predictive Accuracy of Mechanistic Vs. Hybrid Metabolic Models for Process Scale-up
Nick Austin

04:42 PM

(224e) Machine Learning Driven Capability Curves for Commercial Lyophilizers
Matej Zadravec, Fay Metsi-Guckel, Matija Zaloznik, Blaz Kamenik, Peter Dsouza, Johannes Khinast, Avik Sarkar, Petr Kazarin

05:00 PM

(224f) System Identification for Robust Simulation of Freeze/Thaw Processes
Kirk Roffi

05:18 PM

(224g) Simulation of a Vial Filling Process for a None-Newtonian Biologic Product
Nima Yazdanpanah, Patrick Folz

05:36 PM

(224h) Translation of Lnp Mixing Conditions By Micromixing Time Mapping
Jingfan Yang, Kenneth Rodriguez, Daniel Estabrook, Muhan Zhou, Dylan Charland, Geoff Nash, Byungkook Lee, Michael Zhou