2025 AIChE Annual Meeting

Session: Predictive Scale-Up/Scale-Down with Mixing and CFD

Chair

Co-Chairs

Kevin Stone, Merck & Co., Inc.

Presentations

08:00 AM

(664a) Development and Scale-up of a Biphasic Batch Isolation for a Pharmaceutical Intermediate
Katharina Grohowalski, Joseph Imbrogno, Alexander Hesketh, Heather Boucher, Steven Guinness, Iain Gladwell, Gemma Scotney, Christina Connor, Kevin Girard, Vaclav Svoboda

08:21 AM

(664b) Design Space Identification for Reliable Batch Blending Operation Scale-up Using Empirical Correlations in Pharmaceutical Manufacturing
Kanishka Ghosh, Joel Francis, Joshua Hanson, Salvador García Muñoz, Maitraye Sen

08:42 AM

(664c) Multiphysics CFD Modeling of Free-Surface and Heat Transfer in Plant-Scale Stirred Tanks: Revealing Scale-Dependent Process Dynamics
Guanyang Liu, Yuanxing Liu, Kaushalendra Chaturvedi, Lilivet Ubiera, Yasser Jangjou

09:03 AM

(664d) From Lab to Plant: Effective Mixing and Scale-up Strategies for Semi-Batch Processes in the Pharmaceutical Industry
Rajshree Chakrabarti, Eric Hukkanen, Mariya Khiterer, Philip Hogan, Rahul Patil

09:24 AM

(664e) Leveraging Computational Fluid Dynamics for Biopharmaceutical Development and Manufacturing
Chadakarn Sirasitthichoke, Ishaan Shandil

09:45 AM

(664f) Advancing Biopharmaceutical Process Development: The Role of Computational Fluid Dynamics and Digital Twins in Standardizing Scale-up and Scale-Down Strategies
Aparajita Dasgupta, Santiago Garay, Alaina Anand, Aravindan Rajendran

10:06 AM

(664g) Digital Twin for Mixing in Ultrafiltration/Diafiltration Using Computational Fluid Dynamics
Matthew Flamm, Morgan Ayres, Jiemin Wu, Pablo Alvarez Estevez