Plant pathogens represent a significant threat to global food security, and climate change is expected to worsen these challenges. The growing pathogen threat demands the development of novel technologies, as current agrochemical solutions may prove inadequate in the near future. In this work, we explore two distinct approaches using rationally designed nanocarriers to enhance plant pathogen resistance. First, we develop nanocarriers that utilize a biorecognition-based strategy for the species-independent targeted delivery of antimicrobial compounds to stomata to reduce pathogenicity. Second, we introduce programmable covalent organic framework (COF)-based volatile organic compound (VOC) emitters that mimic natural plant defenses by providing a sustained, long-term release of VOCs to deter pathogens. Both approaches demonstrate effective pathogen deterrence, highlighting the multifaceted potential for improving pathogen defense and paving the way for advancements in plant nanobiotechnology and sustainable agriculture.
