Lignocellulolytic enzymes can convert lignocellulose into fermentable sugars under mild conditions, which plays an important role in the sustainable valorization of lignocellulosic wastes with less energy consumption. Fungal production of these enzymes offers the advantages of high enzyme diversity, high production efficiency and low risk of contamination and enzyme degradation. Moreover, fungus is naturally adapted to low-moisture environment, allowing it to utilize solid wastes with minor pretreatment. Aspergillus brasiliensis is a promising strain for lignocellulolytic enzyme production. Under optimal conditions of initial pH, fermentation time, and cultivation temperature, a lignocellulolytic enzyme mix can be efficiently produced by this strain, using wheat bran as substrate and inducer, via solid state fermentation. The collected enzyme mix has high activity of converting wheat bran into reducing sugars.