2025 AIChE Annual Meeting

(445c) Nanoseeding: An Innovative Approach for the Crystallization of Tailormade API Particles.

Authors

The control of particle size distribution is a traditional goal of crystal engineering, with a particular focus towards increasing the release rate of active ingredients from the solid phase. In the quest of developing new, more efficient methods to this end, we developed the concept of nanoseeding. This technology has emerged as a promising technique in the field of pharmaceutical manufacturing, offering a sophisticated method for the crystallization of active pharmaceutical ingredients (APIs). Our contribution discusses the principles, advantages, and applications of nanoseeding in creating tailored particles, thereby circumventing the limitations of conventional micronization processes.

Nanoseeding involves the introduction of nanoscale seed particles to initiate the crystallization process of pharmaceutical compounds. Unlike traditional micronization, which often results in broad particle size distributions, nanoseeding provides a controlled environment for crystal growth, increasing uniformity and high-quality particles. Other than the manipulation of crystal size of the dry powder the particle size distribution can be influenced by simply changing the amounts of seed particles.

This presentation will explore the fundamental mechanisms of nanoseeding, including seed preparation, crystallization, isolation and drying. It will also highlight recent advancements in the technique and its application in the pharmaceutical industry. Case studies will be presented to demonstrate the practical benefits of nanoseeding in the production of high-quality pharmaceutical compounds. Furthermore, the discussion will address the challenges and future directions in nanoseeding technology, emphasizing its potential to transform pharmaceutical manufacturing.