Implant-associated complications—including infections, immune responses, and insufficient tissue integration—pose substantial risks to patients, often leading to implant failure or the need for revision surgeries. Traditional chemical-based approaches, such as antibiotic coatings, face challenges due to limited effectiveness, narrow therapeutic windows, and potential toxicity. Surface topography has emerged as a promising alternative, yet most designs are tailored to single cell types and do not fully account for the dynamic, multicellular interactions at the implant–host interface. In this study, we introduce a multifunctional platform featuring hybrid nano-micro wrinkled topographies, fabricated using a bottom-up nanomanufacturing process. This system simultaneously targets bacteria, immune cells, and tissue progenitors, promoting antibacterial action, immune regulation, and tissue regeneration. Through co-culture models and transcriptomic analysis, we demonstrate that nanoscale features hinder bacterial adhesion, while microscale features facilitate macrophage polarization and osteogenic differentiation via mechanotransduction. Macrophages exhibit context-dependent behavior, switching between pro-inflammatory responses during infection and anti-inflammatory responses for tissue repair, thereby creating a balanced immune environment conducive to implant integration. The flexible and modular nature of this platform offers a versatile solution for developing next-generation biomaterials applicable to diverse medical applications.
I also wish my abstract to be considered for the Biomaterials Graduate Student Award Session. Thanks
Reference
- Asadi Tokmedash M, Kim C, Chavda AP, Li A, Robins J, Min J, Engineering Multifunctional Surface Topography to Regulate Multiple Biological Responses, Biomaterials, 2025, https://doi.org/10.1016/j.biomaterials.2025.123136
- Asadi Tokmedash M, Min J, Designer Micro-/Nanocrumpled MXene Multilayer Coatings Accelerate Osteogenesis and Regulate Macrophage Polarization, ACS Appl. Mater. Interfaces, 2024, https://doi.org/10.1021/acsami.3c18158
- Asadi Tokmedash M, Nagpal N, Chen PY, VanEpps JS, Min J, Stretchable, Nano‐Crumpled MXene Multilayers Impart Long‐Term Antibacterial Surface Properties, Adv. Mater. Interfaces, 2023, https://doi.org/10.1002/admi.202202350
