Synthetic biology is an interdisciplinary discipline that transforms principle and breakthroughs in life sciences and related fields into technological innovations and bioeconomy with engineering approaches, and is the foundation of biomanufacturing. Their combination is a disruptive technology, which is a major direction for the green and sustainable development of the economy and society, and for carbon neutrality. Biomanufacturing is closely related to the grand challenges facing the humankind, especially regarding climate change, food and energy supply. I will first briefly describe the development trend and needs of synthetic biology, and then share some of my experiences in synthetic biology and biomanufacturing from pathway breakthrough to process development with examples, including the latest progress in industrial bioprocess development for diol biosynthesis, one-carbon compound (CO2, methanol etc.) bioconversion (C1-Cx synthetic biology), and catalytic soft-matter synthetic biology using novel biocondensates for future biomaterials, food and biomedicine.
