(521b) A High-Throughput, Size-Resolved Elemental Analysis Technique for Nano-Catalysts

Nanoparticle size and composition are central to catalyst performance, yet conventional techniques for obtaining this information often require extensive sample preparation and lengthy electron microscopy sessions. The work described here introduces a high-throughput methodology that integrates a scanning mobility particle sizer with inductively coupled plasma mass spectrometry to achieve simultaneous size-resolved elemental analysis of multicomponent nanocatalysts in minutes.

The new approach classifies particles based on their electrical mobility, then determines elemental composition using mass spectrometric technique. Dynamic shape factor corrections enable accurate size measurements for a variety of morphologies, including both cubic and tetrahedral nanoparticles. This method is demonstrated on copper-silver and cobalt-nickel-tin nanocatalysts, which are relevant for carbon dioxide reduction and oxygen evolution reactions, respectively. Results align closely with those obtained via electron microscopy, confirming both the reliability and the high-throughput nature of this platform.

By providing ensemble-level characterization without the need for time-intensive imaging, this technique addresses a significant bottleneck in catalyst development. The ability to rapidly map size distributions and elemental compositions in a single run supports a more efficient “predict–synthesize–test” cycle. In addition to catalysis, the approach may be extended to other advanced materials that require precise control over size and composition, offering a powerful new tool for research, process optimization, and quality assurance.