Following molecular-level chirality studies, the chirality of nanomaterials has become a newly emerging focal point in the field, catalyzed by the discovery of intense polarization rotation in individual nanoparticles (NPs) and their assemblies. The uniquely high values of their chiral anisotropy factors, which mainly arise from strong resonances between incident electromagnetic waves and plasmonic and excitonic states typical of metals and semiconductors, can offer: (1) photon-to-matter chirality transfer during chemical synthesis, (2) strong and sensitive chiroptical activity in both linear and nonlinear regimes, and (3) exotic enantioselective interactions with chemical compounds, biomolecules, and cells. In this talk, I will discuss the understanding of asymmetric light-matter interactions and how to leverage these interactions to develop chiral nanomaterial-based high-throughput platforms, using both experimental and computational approaches to overcome current limitations in chiral nanomaterial synthesis and bioanalytical chemistry. The first part focuses on discovering symmetry-breaking factors to control assembly pathways for complex superstructures with chirality and to develop completely solution-processable chiral nanomaterial printing (synthesis) techniques. The second part explores the practical applications of chiral nanomaterials, aiming to overcome limitations in bioanalytical chemistry and discussing their future potential. Understanding and ultimately utilizing chiral nanomaterials and their asymmetric light-matter interactions offers highly efficient pathways for innovative material design strategies, particularly in manufacturing and processing techniques that enable next-generation healthcare advancements, such as disease screening for early diagnosis and immunotherapy.
