The mission of the Chemical, Bioengineering, Environmental, and Transport Systems (CBET) Division of NSF’s Directorate for Engineering is to support innovative research and education in the fields of chemical engineering, biotechnology, bioengineering, and environmental engineering, and in areas that involve transformation and/or transport of matter and energy by chemical, thermal, or mechanical means. CBET research and education investments contribute significantly to the knowledge base and to the development of a 21st century workforce for major components of the U.S. economy, including chemicals, pharmaceuticals, medical devices, forest products, metals, petroleum, natural gas, food, textiles, energy utilities, alternative energy sources, microelectronics, and other sectors. Support for environmental research encompasses pollution prevention and remediation as well as life cycle analysis. This talk will discuss opportunities for submitting research ideas to the core programs of the division covering broad clusters of chemical process systems, transport phenomena, engineering biology and health, and environmental engineering and sustainability. More broader research opportunities that CBET participates in will also be discussed.