2025 AIChE Annual Meeting

(385av) Designing Biomanufacturing Platforms for Bioindustries: A Hybrid Approach Using Experimentation, Process Modeling, and CFD

Author

Somesh Mishra - Presenter, IIT Delhi, India
Research Interests

I work to develop and establish a sustainable and scalable bioprocessing solution to manufacture chemicals, proteins, and biologics. I am skilled at precision fermentation, scale-up, computational modeling, techno-economic analysis, and bioprocess automation. I am deeply involved in engineering bioprocesses to enhance performance, improve scalability, and technology transfer that contribute to a more sustainable bioeconomy. I mostly worked on collaborative projects of high importance nationally/internationally, which has taught me to maintain close association with all institutional departments. This allows us to benefit from different viewpoints and strengths while narrowing the global conservation of science. My core com

Core Skill-set

Scale-Up & Biomanufacturing

  • Translating lab-scale processes to pilot and industrial scale
  • Continuous manufacturing platform development for biotherapeutics
  • Downstream Process development to recover targeted products
  • Understanding of mass transfer, mixing, and reactor hydrodynamics in scale-up
  • Familiarity with tech transfer documentation and validation protocols

Modeling & Simulation

  • Process simulation using tools like MATLAB, SuperPro Designer, PYTHON and Excel-VBA automation
  • Computational Fluid Dynamics (CFD) for multiphase bioreactor analysis (gas-liquid transfer, flow fields)

Techno-Economic

  • Strong background in techno-economic analysis (TEA) for bioprocess evaluation
  • Life cycle analysis and process sustainability insights (circular economy, valorization of waste)

Automation & Data Integration

  • Process automation and control (MATLAB scripting, VBA)
  • Data-driven decision making with custom-built analysis
  • Integrating real-time monitoring with modeling workflows

Specialized Domains

  • Chemicals and alternative protein biomanufacturing
  • Biotherapeutics production and platform process development
  • Biomass valorization using unconventional feedstocks (e.g., lignin, produced water)
  • Sustainability-driven innovation (circular bioeconomy, clean tech applications)