This presentation introduces an innovative biomass processing technology that combines mechanochemical treatment with green solvent systems to optimize the utilization of forest residues. Mechanochemistry encompasses a set of processes employing mechanical forces to perform chemical reactions, serving as a replacement or complement to traditional activation methods of chemical reactions. In the context of biomass conversion, mechanochemistry has been utilized in biomass fractionation with the goal of breaking the linkages between its components, preparing them for further valorization. Central to this approach is the development of bio-compatible deep eutectic solvents (DES), which enable a simplified, one-pot system for biomass fractionation and conversion. By integrating DES with mechanochemical processes, this method eliminates the need for harsh chemicals and reduces energy requirements, addressing key environmental challenges associated with traditional biomass processing. This process is designed to maximize resource efficiency, yielding high-quality lignin streams and fermentable hydrolysates suitable for renewable material production and bioenergy applications.