A mechanistic powder tabletability equation is applied to showcase its ability to guide the development of Hot Melt Extrusion Amorphous Solid Dispersions by incorporating physical particle properties into the prediction of tablet tensile strength based on the bonding strength and bonding number. This investigation aims to establish insights between the interplay of particle and material properties including primary particle size, Sauter mean diameter, surface energy, Young’s modulus, and poison ratio to calculate the bonding strength and bonding number with tablet porosity and compaction pressure. Amorphous Solid Dispersions (ASD) are a promising path forward to increase the bioavailability of active pharmaceutical ingredients, yet fundamental understanding lacks for the creation of its high-performance solid dosage forms. The primary objective of this study is to quantitatively assess and validate the concept of bonding strength and bonding number. To achieve this, the study will adapt a particle adhesion force model for calculating bonding strength and employ a particle coordination number approach to calculate bonding number of a single component. There are two fitting parameters, plastic parameter k and corrected contact number c are related to powder ductility tendency and contact area after compression, respectively. By leveraging the properties of the particles and specific tablet dimensions, the study aims to establish formulation guidelines. The proposed model is expected to serve as a valuable resource, offering guidance for rational excipient design, rational formulation design, and in subsequent work, estimates of the highest possible drug loading.
