2025 AIChE Annual Meeting

(505f) Advanced Biopharmaceutical Continuous (ABC) Manufacturing Process

Author

Youngbin Baek - Presenter, The Pennsylvania State University
Professor Andrew L. Zydney has made transformative contributions to the field of biopharmaceutical manufacturing, particularly in advancing continuous processing technologies. His pioneering work on ultrafiltration/diafiltration (UF/DF) and virus filtration has significantly improved the efficiency, robustness, and scalability of downstream bioprocessing, laying the foundation for modern continuous manufacturing strategies. His research has provided fundamental insights into membrane transport phenomena, optimizing the performance of UF/DF for protein concentration and buffer exchange in monoclonal antibody (mAb) and vaccine production. Through rigorous experimental and modeling approaches, he has elucidated mechanisms of concentration polarization, membrane fouling, and osmotic effects, enabling the rational design of high-throughput, low-fouling UF/DF systems for continuous operations. In the area of virus filtration, Professor Zydney’s work has driven advances in virus removal technologies, ensuring the safety of therapeutic biologics. His studies on virus retention mechanisms, membrane pore structure, and flow dynamics have led to optimized virus filtration strategies that enhance viral clearance efficiency while maintaining high product yields. His contributions have been instrumental in establishing virus filtration as a critical step in regulatory-compliant biopharmaceutical production.