2024 AIChE Annual Meeting

Session: Mixing Issues in Scale-Up and Scale-Down of Pharmaceutical & Biopharmaceutical Processes

Mixing issues and scale-up/scale-down strategies for the production of pharmaceutical and biopharmaceuticals.

Chair

Flamm, M., Merck & Co., Inc.

Co-Chair

Sirasitthichoke, C., New Jersey Institute of Technology

Presentations

08:00 AM

(485a) Mechanistic Insights into How Mixing Factors Govern Polyelectrolyte-Surfactant Complexation in RNA Lipid Nanoparticle Formulation
Dasaro, S., Singh, A., Vlachos, P., Ristroph, K.

08:25 AM

(485b) Studying Micromixing and Phase Transitions in Pharmaceutical Processes: A Phase-Field Modelling and Raman Microscopy Approach
Moreno Flores, I., McKechnie, D., Lue, L., Cardona, J.

08:50 AM

(485c) Applications of Computational Fluid Dynamics for Prediction of Buffer Dissolution in Mixing Tanks for Biopharmaceutical Processes
Partopour, B., Wutz, J., Hazarika, A., Thomas, J.

09:15 AM

(485d) The Hydrodynamics of Vials and Laboratory Bottles
Pace, J., Patel, S., Bredael, G., Hermans, A., Armenante, P.

09:40 AM

(485e) Application of a Computational Methodology for the Prediction of Mab Produced By CHO Cell Clones in pH Heterogeneous Bioreactors
Raudenbush, K., Venkatarama Reddy, J., Attfield, L., Kedge, O., Kotidis, P., Finka, G., Marchese, G., Yang, O., Talwar, S., Hu, Z., Ierapetritou, M.

10:05 AM

(485f) CFD Simulation of the O2 and CO2 Levels in Mammalian Cell Respiration inside an Aerated Stirred Bioreactor
Van den Akker, H., Jamshidian, R.