2024 AIChE Annual Meeting

Session: Mixing Issues in Scale-Up and Scale-Down of Pharmaceutical & Biopharmaceutical Processes

Mixing issues and scale-up/scale-down strategies for the production of pharmaceutical and biopharmaceuticals.

Chair

Matthew Flamm, Merck & Co., Inc.

Co-Chair

Chadakarn Sirasitthichoke, New Jersey Institute of Technology

Presentations

08:00 AM

(485a) Mechanistic Insights into How Mixing Factors Govern Polyelectrolyte-Surfactant Complexation in RNA Lipid Nanoparticle Formulation
Sophia Dasaro, Abhishek Singh, Pavlos Vlachos, Kurt Ristroph

08:25 AM

(485b) Studying Micromixing and Phase Transitions in Pharmaceutical Processes: A Phase-Field Modelling and Raman Microscopy Approach
Irene Moreno Flores, David McKechnie, Leo Lue, Javier Cardona

08:50 AM

(485c) Applications of Computational Fluid Dynamics for Prediction of Buffer Dissolution in Mixing Tanks for Biopharmaceutical Processes
Behnam Partopour, Johannes Wutz, Abhinav Hazarika, John Thomas

09:15 AM

(485d) The Hydrodynamics of Vials and Laboratory Bottles
Justin Pace, Sanjaykumar Patel, Gerard Bredael, Andre Hermans, Piero Armenante

09:40 AM

(485e) Application of a Computational Methodology for the Prediction of Mab Produced By CHO Cell Clones in pH Heterogeneous Bioreactors
Katherine Raudenbush, Jayanth Venkatarama Reddy, Luisa Attfield, Omkar Kedge, Pavlos Kotidis, Gary Finka, Giulia Marchese, Ou Yang, Sameer Talwar, Zhonghe Hu, Marianthi Ierapetritou

10:05 AM

(485f) CFD Simulation of the O2 and CO2 Levels in Mammalian Cell Respiration inside an Aerated Stirred Bioreactor
Harry Van den Akker, Roya Jamshidian