2024 AIChE Annual Meeting

Optimization and Characterization of 3D Printed Solid Oral Dosage Forms

This research focuses on the dosage, characterization, and standardization of three-dimensionally (3D) printed pharmaceutical tablets, highlighting the innovative potential of additive manufacturing in modern drug delivery systems. The study delineates the methodologies, parameters, and formulations required for the bio-ink utilized in the 3D printing process. A robust calibration curve was developed and rigorously validated using UV-Visible Spectrophotometry, facilitating the precise quantification of caffeine uniformity within the printed tablets.

The findings indicate a significant improvement in the content uniformity of 3D-printed tablets compared to those produced via conventional pharmaceutical manufacturing techniques, underscoring the advantages of precision, accuracy, and customization inherent in 3D printing. This advancement suggests a transformative shift in pharmaceutical manufacturing, allowing for tailored dosages and personalized medicine that can better meet individual patient needs.

Future investigations should prioritize a comprehensive evaluation of the mechanical properties of 3D-printed tablets, specifically their hardness, disintegration time, and friability, to further ascertain their quality, efficacy, and reliability for clinical applications. Additionally, exploring the scalability of this innovative technology and its integration into existing pharmaceutical frameworks will be essential for practical implementation and broader adoption. This study lays the groundwork for subsequent research aimed at optimizing 3D printing processes for pharmaceuticals and enhancing their overall effectiveness.