2024 AIChE Annual Meeting
Assessing Release Profile of Electrospraved Polymeric Coatings
Electrospraying is an efficient technique for producing polymeric coatings with smooth topographies. This technique stands out for its ability to create reproducible coatings in ambient conditions from a plume of charged droplets. These polymeric coatings can be uniformly fabricated to incorporate potential drug molecules for delivery. The primary goal of this study is to develop model drug-loaded films that exhibit controlled release into a medium, specifically Phosphate Buffered Saline (PBS). To simulate in vivo conditions, we employed a thermal shaker and replenished the PBS after each model drug concentration measurement. We determined the total cumulative percentage of drug release for model drug Rhodamin B (RhB) over time. The controlled release observed was a result of exploiting the change in the glass transition temperature (Tg) of the polymer, Polyvinyl Acetate (PVAc). Tailored drug release is highly sought after in various medical treatments, including cancer therapy. Moving forward, we intend to investigate controlled released coatings to generate tunable and distinctive release curves.