(735bf) Streamlining Bone Scaffold Production: Automation and Innovative Approaches

Bone scaffold fabrication is a major pillar in tissue engineering, yet scalability and reproducibility are challenges for conventional fabrication methods. This study aims to propose an innovative experiment design to leverage automation and innovation to enhance bone scaffold fabrication. 3D printing, material handling, and process optimization are components that achieve efficiency, consistency, and scalability improvements. Precise measurements were implemented for material handling challenges. A reduction in material waste was seen as a result. A mesh filter was developed to enhance scalability. The Filter enabled experimentation with multiple scaffolds while maintaining individual identity and measurements. This increased throughput, streamlined workflow, and improved efficiency. The highlight of our methodology is integrating automated casting with bioprinting technology. Through these improvements, higher precision and reduced processing time were attained. With the automated casting process, we were able to achieve over 5 times faster fabrication compared to manual methods, demonstrating scalability and efficiency gains. The focus is to produce high quality scaffolds, leveraging automation and innovation for advancing scaffold fabrication. This paper presents the experimental procedure in detail, the emphasis is on material handling improvements, as well as scalability solutions, and integrating automated casting. The end goal is optimizing the scaffold fabrication process, to advance tissue engineering.