(735al) Dissolution and Friability Analysis of Commercial and Lab-Developed Apap Tablets

Previous research has sought to enhance fundamental knowledge in the area of particle interactions in acetaminophen (paracetamol, APAP) tablets by evaluating the performance of tablets formed using a single binding material or excipient. In comparison, commercially available brands of APAP may contain between 5-15 inactive ingredients. The selection of excipients can either improve or decrease tablet properties such as the bioavailability of the active pharmaceutical ingredients (API). To enhance patient safety, it is crucial to comprehend the relationship between APAP and various excipients. This research provides an analysis of commercial APAP tablets and lab-formed APAP tablets. The main goal is to create a drug that is easy for users to take without causing any adverse reactions to the non-medicinal ingredients. Dissolution and friability tests were used to measure tablet performance of regular strength (325 mg) including circle and oblong shapes. Tablet size and shape analysis was determined using Image Pro Premiere software. Most lab-formed tablets performed outside of the USP threshold of 1% max friability while the commercial brands had less than 0.5% friability. Disintegration experiments show an immediate loss of structure within the first 3 minutes for most tablets. The tablet shape, the amount of inactive ingredients, and the type of excipient affected the dissolution rate of the APAP tablet. The results emphasize the importance of continuous research to improve the composition and administration of APAP while addressing the changing sensitivities of patients worldwide.