(495f) Residence Time Distribution Implication Is Continuous Crystallization

The Residence Time Distribution (RTD) is mostly treated as an equipment characterization and sub-category of momentum transport phenomena. This could not be correct if a disturbance impacts the product, reaction, or crystallization. In the case of continuous crystallization the extent of RTD firstly depend on the crystallization mechanism, for example if that is reactive crystallization (then also the chemistry is involved), if the impurity inclusion highly depends on kinetics, or PSD depends on mixing or residence time. Other aspects are also depend on the type of the crystallizer (i.e. MSMPR, Plug Flow,...) or type of disturbance (e.g. Crystallizer temperature, flow rates, mixing rpm, impurity at inlet,...) and significance of disturbance (magnitude and duration). Then the importance of the RTD understanding would be significant according to the context of use, if the RTD should be used in process control or the RTD directly will impact the CQA (e.g. PSD, or impurity inclusion).

In this presentation we will discuss on different complications of the RTD in continuous crystallization, some disturbances, and with an industrial case study to demonstrate the RTD at a large scale manufacturing.