2024 AIChE Annual Meeting
(489f) Flame-Made Fluorescent Nanothermometers Enable Superior Control in Laser Tissue Soldering
However, the efficacy of laser tissue soldering heavily relies on precise temperature control throughout the procedure. Our research introduces a novel approach to this challenge, employing controlled laser tissue soldering guided by fluorescent nanothermometers. These flame-made nanoparticles, seamlessly integrated into protein-based solders, offer non-invasive temperature monitoring. As a significant advancement towards more precise and less invasive soldering techniques, we demonstrate temperature distribution measuring and fluorescence guidance of the soldering process for high-performance outcomes. This is made possible by incorporating an intelligent solder paste containing near-infrared (NIR) fluorescent nanothermometers and nanoabsorbers like titanium nitrate nanoparticles.
Furthermore, our work includes various strategies to guide surgery by analyzing the temperature distribution based on nanothermometry and fluorescence during soldering, thus optimizing results.