(440c) 3D Printed Biosponge Polymer Adsorber for Capturing Hazardous Chemotherapy Drugs to Reduce Chemotherapy Toxicities in the Body

3D printing of multifunctional polymers can form previously nonexistent 3D complex structures that are difficult to prepare via conventional polymer processing. Integration of polymer chemistry with 3D printing leads to new polymer structures, opening a new door for biomedical separation. Here, we have designed, built, and deployed porous biosponge adsorbers for capturing chemotherapy drugs from the blood stream after these drugs have had their effect on a tumor, but before they are spread through the body where they can cause hazardous side effects. The support structure of the adsorbers was built using the continuous liquid interface production (CLIP). This structure was coated with a nanostructured block copolymer with outer blocks that anchor the polymer chains to the 3D printed support structure and a middle block that has an affinity for the drug. The middle block is polystyrenesulfonate which binds to doxorubicin, a widely used and effective chemotherapy drug with significant toxic side effects. The adsorbers are designed for deployment during chemotherapy using minimally invasive image-guided endovascular surgical procedures. We show that the introduction of the adsorbers into the blood of swine models enables the capture of 64 ± 6 % of the administered drug (doxorubicin) without any immediate adverse effects. This development represents a significant step forward in minimizing toxic side effects of chemotherapy.