(295c) Amplifying Flutamide Sensing through the Synergetic Combination of Actinidia-Derived Carbon Particles and WS2 Platelets

The research into electrochemical sensors for detecting flutamide has reached a critical juncture in the realms of biomedical and environmental monitoring. A study was conducted where spherical carbon particles (CPs) were obtained from Actinidia fruit juice through a simple Hydrothermal method. These CPs exhibit a unique characteristic of appearing green under UV light and fluorescing with a maximum emission upon excitation with light at 350 nm. Despite having an average diameter of 500 nm (Spherical Shape), the presence of carbon dots decorating the CPs appears to be responsible for this unusual fluorescence. The CPs were then combined with tungsten disulfide (WS₂) using ultrasonication and centrifugal mixing, resulting in the formation of a CPs-WS₂ nanocomposite. The interaction between WS₂ and CPs showcased a clear synergetic effect, with their sizes and dimensions facilitating efficient electron transfer due to a high surface area.

The CPs-WS₂ nanocomposite-modified glassy carbon electrode (GCE) displayed excellent performance in detecting flutamide, with a linear concentration range spanning from 1 nM to 104 µM, a low limit of detection (LOD) at 0.74 nM, and a high sensitivity of 446.7 µA µM⁻¹cm⁻² in a phosphate buffer solution. Furthermore, the sensor demonstrated good recovery rates ranging from 88.47% to 95.02% in river water samples and exhibited high selectivity towards flutamide even in the presence of various inorganic ions. The GCE/CPs-WS₂ sensor exhibited impressive stability, excellent selectivity, high sensitivity, and satisfactory recovery results in complex canal/river water and artificial urine samples, highlighting its potential for determining flutamide in both environmental and biomedical applications.The Actinidia-derived CPs-WS₂ nanocomposite sensor shows considerable promise for the sensitive and selective detection of flutamide across varied environmental samples. This research underscores the importance of developing advanced sensing materials for pharmaceutical detection in water sources and proposes potential applications of carbon-based nanocomposites in electrochemical sensing. Future studies could potentially concentrate on optimizing sensor performance and exploring real-world applications in environmental monitoring.