2024 AIChE Annual Meeting
(26a) Invited Talk: Induced Proximity As a Biodesign Strategy to Engineer Mammalian Cells
Author
Dickinson, B. C. - Presenter, University of Chicago
Non-covalent interactions between biomolecules such as proteins and nucleic acids coordinate all cellular processes through changes in proximity. Technologies that perturb, control, or reprogram these biomolecular interactions can be used to alter mammalian cell signaling for both basic research and as platform therapeutic biotechnology. I will present our group's work toward harnessing novel evolution platforms and engineering strategies to study and control biomolecular interactions. Collectively, our work highlights how advances in synthetic biology can lead to novel functional molecules that provide solutions to challenges in biotechnology and medicine.