2024 AIChE Annual Meeting
(169ba) Physical Simulations of Genome Organization and the Histone Code
The three-dimensional structure of chromatin is increasingly understood to be a major player in determining gene regulation and genome function. Interest has risen in the prospect of therapeutics that are engineered to tailor the functional role of chromatin by modulating its’ 3D structure. However, while
some new biochemical methods are available to precisely edit epigenetic marks in vivo, very little is known about the downstream effects of these edits on chromatin physical organization. We present a physical model for genome organization which represents epigenetic marks explicitly, enabling for the first time de novo epigenetic engineering in a predictive manner.
some new biochemical methods are available to precisely edit epigenetic marks in vivo, very little is known about the downstream effects of these edits on chromatin physical organization. We present a physical model for genome organization which represents epigenetic marks explicitly, enabling for the first time de novo epigenetic engineering in a predictive manner.