2024 AIChE Annual Meeting
(145e) Scale Down Studies for Complex Fluids Compounding Using Multiphase Simulation.
Authors
Ganji, A. R., Pfizer Global Supply
Kadam, S. S., Pfizer Global Supply
Selvakumari, V., Pfizer Global Supply
Narasimharaghavan, S., Pfizer Global Supply
Simard, J. S., Pfizer Canada
Awasthi, A., Pfizer Global Supply
The study investigates the application of multiphase simulation techniques for conducting scale-down studies of complex fluid mixing. Complex fluids, such as emulsions, suspensions, and foams, play a crucial role in various industrial processes, including pharmaceuticals, food, and oil and gas. Understanding their behaviour at different scales is vital for process optimization, cost reduction, and product quality improvement. However, experimental scale-down studies can be challenging and costly due to the intricate nature of these fluids. In this research, we propose the utilization of multiphase simulations as a cost-effective alternative to experimental scale-down studies. By employing advanced computational fluid dynamics (CFD) models, we can accurately capture the complex dynamics, including rheological properties of the fluids. The results show that multiphase simulations provide valuable insights for the identification of key process parameters and optimization of scale-down studies. Overall, this study demonstrates the potential of multiphase simulations as a powerful tool for scale-down studies of complex fluids, offering significant benefits in terms of cost, time, and process understanding.