2023 AIChE Annual Meeting

Session: Predictive Scale-Up/Scale-Down for Pharmaceuticals and Biopharmaceuticals #2

Chair

Onkar Manjrekar, AbbVie Inc.

Co-Chairs

Presentations

12:30 PM

(656a) Digital Design of a Small Molecule Oral Suspension Homogenization Process
Kiran Iyer, Martin Rowland, Pankaj Doshi, Michaela Ogden-Barker, Dan Wu-Linhares, David Jones, Jason Edwards, Robert Leasure, Ying Zhou, Austin Mashburn, Sai Santhosh Manepally, Mangesh Gavade

12:51 PM

(656b) Using Bayesian Modeling and Crystallization Fundamentals to Develop a Robust Particle Size Control Strategy
Troy Wilkens, Benjamin M. Cohen, Uday Jain, Ajay Saxena

01:12 PM

(656c) In silico Process Design and Scale-up for an Amorphous Solid Dispersion Manufactured By Hot Melt Extrusion
Josip Matic, Jonathan Meyer, Rohan Ambardekar, Mark McAllister, Mark Pinto, Pankaj Doshi, Johannes G. Khinast, Dalibor Jajcevic

01:33 PM

(656d) Underlying Mechanisms Leading to a Wet Milling Process Grinding Limit As a Function of Scale
Michael Filios, Carla Luciani, Mary Eccles

01:54 PM

(656e) Robust Process Design for a Terminal Wet Milling Process
Mary Eccles, Carla Luciani, Mike Filios

02:15 PM

(656f) Rapid Development of Nirmatrelvir Tablets Using Digital Design and Predictive Science
Pankaj Doshi, Senthil Kumarasamy, Kiran Iyer, Daniel O. Blackwood, Peiyuan Liu, Patrick Daugherity, Alfred Berchielli, Weili Yu, Denis Kaydanov

02:36 PM

(656g) Hybrid Modeling of Roller Compaction and Tableting for Accelerated Oral Tablet Product
Kiran Iyer, Senthil Kumarasamy, Denis Kaydanov, Pankaj Doshi, Daniel O. Blackwood, Allan Hutchins, Patrick Daugherity, Holger Schlack, Weili Yu