2023 AIChE Annual Meeting

Session: Foreign Species and Crystallization: Impurity Rejection, Additives, Dopants, etc.

Chair

Gerard Capellades, Massachusetts Institute of Technology

Co-Chairs

Torsten Stelzer, Crystallization Design Institute
Eric Sirota, Merck & Co.

Presentations

03:33 PM

(324a) Prevalence of Impurity Retention Mechanisms in Pharmaceutical Crystallizations
Fredrik Nordstrom, Eric Sirota, Gerard Capellades, Thomas Kwok, Huayu Li, Vincent Abeyta, Tommasina Bramante, Taylor Behre, Mitchell Paolello, Clara Hartmanshenn, Emma Madrigal

03:51 PM

(324b) Crystallisation Process Design for the Separation of Dipeptides Based on Alanine and Glycine with Antisolvent Addition
Enshu Liang, Mingxia Guo, Vivek Verma, Jerry Heng, Emily J. Guinn

04:09 PM

(324c) Purity Reigns Supreme over Stability and Processibility!! .. but Wait, Why Can’t I Have My Cake and Eat It Too?
Nandkishor Nere, Ann M. Czyzewski, Manish Kelkar, Alessandra Mattei, Troy Reynolds, Alan Christesen, Michael Rozema, Bradley Greiner

04:27 PM

(324d) Population Balance Modeling of Kinetic-Controlled Incorporation of Structurally Related Impurities for Crystallization Systems
Baggie W. Nyande, Helen Yao, Chris Davey, Samir Diab, Zoltan Nagy

04:45 PM

(324e) Effect of Lattice Incorporated Impurities on Crystallization of a Pharmaceutical Compound. a Case Study in Early Development.
Vincent Abeyta, Fredrik Nordstrom

05:03 PM

(324f) Principles for Designing Effective Modifiers of Calcium Oxalate Monohydrate Crystallization and Dissolution
Vraj Chauhan, Jeffrey Rimer

05:21 PM

(324g) Effects of Impurity Nanoparticles in Microfluidic Non-Photochemical Laser Induced Nucleation of Potassium Chloride
Ryan Hartman, Kelechi Ndukwe-Ajala, Bruce A. Garetz, Ishani Prachchhak, Jasmin Sabirin, Jaewon Lim

05:39 PM

(324h) Molecular Mechanisms Employed By Antimalarial Drugs to Control Hematin Crystallization
Wenchuan Ma, Lakshmanji Verma, Weichun Pan, Michael Sherman, Jeremy Palmer, Peter Vekilov