2023 AIChE Annual Meeting

Session: Advances in New Modalities: Discovery and Production

Chair

Xiaoxiang Zhu, Amgen Inc

Co-Chairs

Christopher Lowe, University of Massachusetts-Amherst
Qin Gu, Carnegie Mellon University

Presentations

08:00 AM

(485a) Scalable One-Pot Liquid Phase Oligonucleotide Synthesis Enhanced By Organic Solvent Nanofiltration
Ronan Kelly, Catalina Parga, Steven Ferguson

08:20 AM

(485b) Mechanistic Modeling to Enhance Production of Recombinant Adeno-Associated Virus with Insect Cells
John Joseph, Francesco Destro, Prasanna Srinivasan, Richard D. Braatz, Robert Kotin, Sylvain Cecchini, Joshua Kanter, Caleb Neufeld, Jacqueline M. Wolfrum, Paul W. Barone, Stacy Springs, Anthony Sinskey

08:40 AM

(485c) Development of Solid Phase Peptide Synthesis Kinetic Models for Impurity Control Strategies
Jingyao Wang, Mark Berglund, Jonas Y. Buser, Matthew C. Embry, Jennifer M. Groh, Michael Kopach, Adam D. McFarland, Kevin Seibert, Shekhar Viswanath

09:00 AM

(485d) Mechanistic Modeling, Optimization, and Control of in-Vitro Transcription for mRNA Production
Nathan M. Stover, Krystian Ganko, Richard Braatz

09:30 AM

(485e) Coarse-Grained Molecular Dynamics Simulations of Adsorption of Adeno-Associated Virus Onto Ion-Exchange Chromatographic Media
Tibo Duran, Shivangi Naik, Arani Chanda, Willow DiLuzio, Bodhisattwa Chaudhuri, Jake Kneski

09:50 AM

(485g) Robust Biomanufacturing of Recombinant AAV for Cardiac-Specific Gene Delivery
Seulhee Kim, Kai Chen, Xiaoguang Liu, Lufang Zhou

10:10 AM

(485h) Mab-Exo-AAV-Mediated Targeted Gene Therapy to Treat Triple-Negative Breast Cancer
Tanvi Varadkar, Xiaoguang Liu, Lufang Zhou, Zhuoxin Zhou, Kai Chen, Jiashuai Zhang