2023 AIChE Annual Meeting
(198d) Development and Application of Residence Time Distribution (RTD) Models for a Continuous Direct Compression Process
Authors
In addition, advanced control systems and process analytical technologies must be in place to ensure consistent product quality and enable the productâs real-time release. To this end, a thorough study of the process dynamics is also needed to estimate the residence times required in each operation to obtain acceptable results and predict how material flow disturbances propagate through the manufacturing line and influence the final product. This characterization of process dynamics is usually performed with a residence time distribution (RTD) analysis of the line.
This work highlights the application of RTD models in the development of a Continuous Direct Compaction (CDC) process. It is shown how the RTD model of individual unit operations can be calibrated with a minimal set of experiments. Case studies are presented where the impact of variabilities in mass flows of feeders and blenders on assay profiles with different intensities and duration are analyzed. Results are discussed in the view of using RTD models to compare robustness of different process setups during process development and to design strategies for in-process control.