2022 Annual Meeting

Session: Predictive Scale-Up/Scale-Down for Production of Pharmaceuticals and Biopharmaceuticals II

Chair

Onkar Manjrekar, AbbVie Inc.

Co-Chairs

Presentations

08:00 AM

(82a) Implementation of a Small-Scale Capillary Shear Model to Facilitate Process Development of Disc Stack Centrifugation during the Harvest of Biopharmaceuticals
Steven Frey, Jane Liao, Stijn H.S. Koshari, Robert Luo, Antonio Ubiera

08:21 AM

(82b) Using Particle Size Distributions to Predict the Filterability of Materials throughout the Processing of Monoclonal Antibodies
Steven Frey, Hong Zhang, Robert Luo, Antonio Ubiera

08:42 AM

(82c) Predictive CFD Mixing Model for Scale up/Down of Large Molecule Dug Product Formulation
Matthew Flamm, Joseph Rizzo, Hope Seybold, Tracey Mascaro, Avik Sarkar, Shweta Modi, Chandler Amato, Craig Ikeda

09:03 AM

(82d) Model Aided Scale-up of Spray Drying for a Sticky API (low Glass Transition Temperature)
Ankur Kapil, Michael Hamlin, Claire Wombell, Li Liu

09:24 AM

(82e) In silico Modeling of Roller Compaction Processes for Scale-up and Tech Transfer: One Step Closer to Digital Twins
Pablo A. Rolandi, Fabrice Schlegel, Fernando Alvarez-Nunez, John Chung, Mina Hamedi Rad, Shruti Gour, Saloni Daftardar, Duc Nguyen, David Perez-Aguilar, Dongying Shen, Ananya Chowdhury, Elcin Icten Gencer, Maxwell Maritato, Rajarshi Sengupta, Killian Ryan

09:45 AM

(82f) Optimizing the Design and Scale-up of Agitated Filter Dryer
Guilherme Turezo, Sravan Nallamothu, Mahesh Kadam, Ahmad Haidari

10:06 AM

(82g) Scalability and Predictability of Terminal Wet Milling Processes
Carla Luciani, Mary Eccles, Michael Filios