2022 Annual Meeting

Session: Predictive Scale-Up/Scale-Down for Production of Pharmaceuticals and Biopharmaceuticals I

Chair

Onkar Manjrekar, AbbVie Inc.

Co-Chairs

Presentations

03:30 PM

(33a) Synchronized Mixing, Bubble Size Distribution, and KLa High-Fidelity Simulation for Optimization, and Scale-up for Benchtop Biofilm Bioreactor
Nima Yazdanpanah, Jorge Lopez, Ali Demirci, Aydin Berenjian

03:52 PM

(33b) Process Development and Scale-up of an Enzyme Removal Strategy for Drug Substance Manufacturing
Jonathan P. McMullen, Victoria Zhang, Jungchul Kim, Kevin Sirk, Alexandra Sun, Daniel DiRocco, Joshua N. Kolev

04:14 PM

(33c) Scale-Dependency Assessment Strategy to Translate Proven Acceptable Ranges from Small to Commercial Scale
Jacob Santos-Marques, David Am Ende, Mary am Ende, Matthew Burk, Fern Sinclair, Jerry S. Salan, David Leahy, Lopa Bakrania

04:36 PM

(33d) Islatravir Crude Isolation Development and Scale-up: Late-Stage Shift from Filter Dryer to Centrifuge to Mitigate Risks from Enzyme Filtration
Brittany Dobson, Margaret Miller, Daniel Bishara, Matthew Gunsch, Michelle Cleary, David Bell, Aisling Prendergast, Ivan Lee, Darryl Chang, Sandra A. Robaire, Nicholas Rogus, Theodore Furman, Gregory Hughes, Elizabeth Fisher, Kevin Maloney, Junyong Jo, Paula Archbold

05:20 PM

(566c) N-Glycanyzer: An Integrated on-Line Process Analytical Toolkit for Enabling Continuous Biologic Manufacturing
Aron Gyorgypal, Shishir Chundawat

05:42 PM

(33f) Antibody Production Against Camptothecin- Derived Small Molecules :a Tool for Developing Pharmacokinetic Studies and Dose Management Chemotherapy
Tahereh Zarnoosheh farahani