2022 Annual Meeting

Session: Pharma 4.0 (Advanced Controls, Process Automation, Data Analytics, etc.) in Drug Substance and Drug Product II

Chair

Co-Chairs

Dana Barrasso, Process Systems Enterprise (PSE)
Hossein Salami, Georgia Institute of Technology

Presentations

03:30 PM

(567a) Pharma 4.0: Advanced Continuous Pharmaceutical Tablet Manufacturing Process
Ravendra Singh

03:51 PM

(567b) Development of a DEM Based Digital Twin of a Tablet Press Feed Frame for the Evaluation of Continuous Manufacturing Control Strategies.
Dalibor Jajcevic, Johan Remmelgas, Peter Toson, Marko Matic, Michela Beretta, Jakob Rehrl, Julia Kruisz, Thomas O'Connor, Abdollah Koolivand, Geng Tian, Scott M. Krull, Johannes G. Khinast

04:12 PM

(567c) Integrated System Modeling That Connects the Drug Product Manufacturing Process to Dissolution Testing
Indu Muthancheri, Robert Yule, Marilyn Calderone, Cecile Gabaude-Renou, Nicolas Sanchez

04:33 PM

(567d) Hybrid Machine Learning Assisted Model Predictive Control of a Continuous Dry Granulation Tableting Line
Yan-Shu Huang, Sunidhi Bachawala, Marcial Gonzalez, Zoltan Nagy, Gintaras Reklaitis, Rexonni Lagare

04:54 PM

(567e) Smart Process Analytics for the Prediction of Critical Quality Attributes in End-to-End Batch Manufacturing of Monoclonal Antibodies
Moo Sun Hong, Richard D. Braatz, Fabian Mohr, Chris Castro, Tom Mistretta, Roger A. Hart, Ben Smith

05:15 PM

(567f) Characterizing the Freezing Process of Biopharmaceuticals in Vials at Commercial Scale: COVID-19 Vaccine Case Study and Mechanistic Modeling
Leif-Thore Deck, Marco Mazzotti, David R. Ochsenbein

05:36 PM

(567g) Smart Data Analytics for Fault Detection and Its Application to Biopharmaceutical Manufacturing
Fabian Mohr, Weike Sun, Richard D. Braatz