2022 Annual Meeting

Session: Mixing Scale-Up and Scale-Down Issues in Pharmaceutical Processes

Chair

Luis Sierra, Merck & Co., Inc.

Co-Chair

Chadakarn Sirasitthichoke, New Jersey Institute of Technology

Presentations

08:00 AM

(459f) The challenges of detailed CFDsimulations ofstirred lab-scalebioreactors
Roya Jamshidian, Harry Van den Akker

08:30 AM

(459b) Using CFD to Predict Mixing Coefficients for Scale up
Darren Cappelli

09:00 AM

(459c) A Design of Experiment (DOE)-Based Approach for Bioreactor Scale up and Cell Metabolic Reactions
Hossam Metwally, Sravan Nallamothu, Sivasubramani Krishnaswamy, Sophie Collin, Clementine Shao, Marc Horner

09:30 AM

(459d) Scale-Down of Viral Inactivation Step: Principles and Practical Challenges
Zbynek Kalal

10:00 AM

(459e) Application of Gas-Liquid Mass Transfer Coefficient Fitting Techniques in Batch Reactors for Scale-up
Kira Ragazzo, Jeffrey A. Nye, Shulin Wu, Xiaowen Zhao, Candice Joe, Megan Emmanuel, Richard Heid, Antonio C. Ferretti