2022 Annual Meeting

Session: Control Strategies in Pharmaceutical Development and Manufacturing II

Chair

Co-Chair

Christopher Marton, Bristol Myers Squibb

Presentations

03:30 PM

(207a) Mechanistic Study of Diketopiperazine Formation during Solid Phase Peptide Synthesis of Tirzepatide
Jingyao Wang, Mark Berglund, Fareed Sayyed, Matthew C. Embry, Stephen Groskreutz, Martin Johnson, Timothy M. Braden, Michael Kopach

03:51 PM

(207b) Strategies for Mitigation and Control of PS80 Degradation in a Monoclonal Antibody Downstream Process
Hope McMahon, Kevin Chang, Zifan Gong, Andreas Sophocleous, Robert Luo, Antonio Ubiera

04:12 PM

(207c) Eliminating Batch-to-Batch Variability in Monoclonal Antibody Production Using Closed-Loop Control
Thomas Kavanagh, Maria Papathanasiou, Cleo Kontoravdi

04:33 PM

(207d) Systematic Control Strategy Development for a Continuous Direct Compaction Line Via the Control Strategy Evaluation Tool (CET)
Jakob Rehrl, Julia Kruisz, Selma Celikovic, Peter Toson, Dalibor Jajcevic, Johan Remmelgas, Thomas O'Connor, Abdollah Koolivand, Geng Tian, Scott M. Krull, Johannes G. Khinast

04:54 PM

(207e) Modeling, Simulation and Control of Twin-Screw-Granulation and Fluid-Bed-Drying Applied to a ConsiGmaTM-25 Line
Jakob Rehrl, Selma Celikovic, Johannes Poms, Martin Horn, Johannes G. Khinast

05:15 PM

(207g) A Knowledge-Guided Framework for the Effective Application of Machine Learning Models in the Development of Condition Monitoring Systems.
Rexonni Lagare, Zoltan Nagy, Gintaras Reklaitis, Yan-Shu Huang